Gene interactions and pathways from curated databases and text-mining

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MMP2 — NOS2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Keilhoff et al., Dev Neurobiol 2007 (Sciatic Neuropathy...) : Compared with uninjured and PBS treated injured nerves, the minocycline treated injured nerve showed : ( i ) a decrease in macrophage recruitment and activation, probably resulting from inhibition of blood-brain-barrier break-down via reduced MMP2 and MMP9 induction, inhibition of revascularization via additional reduction of VEGF induction, and inhibition of inducible NO synthase (iNOS) induction ; ( ii ) reduced activation of phagocytic Schwann cells, probably by inhibition of iNOS, MMP2 and MMP9 expression ; ( iii ) a slowed Wallerian degeneration ; and subsequently, ( iv ) a diminished nerve regeneration
Chen et al., Toxicological sciences : an official journal of the Society of Toxicology 2008 (Lung Neoplasms...) : Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS mediated MMP-2 production ... Using a mouse model, we showed that gNO promoted A549 metastasis to the lung through a mechanism involving the iNOS dependent MMP-2 activity
Chen et al., Tokai J Exp Clin Med 2008 (Plaque, Atherosclerotic) : Activation of inducible nitric oxide synthase increases MMP-2 and MMP-9 levels in ApoE-knockout mice
Givvimani et al., International journal of physiology, pathophysiology and pharmacology 2011 : Hcy increases iNOS , activates matrix metalloproteinase ( MMP ) , disrupts connexin-43 and increases collagen/elastin ratio
Souza-Pinto et al., J Biomed Mater Res A 2013 (Inflammation) : Inducible nitric oxide synthase inhibition increases MMP-2 activity leading to imbalance between extracellular matrix deposition and degradation after polypropylene mesh implant ... NOS2 inhibition increased MMP-2 activity and resulted in a higher visceral adhesion incidence at the mesh implantation site when compared with non treated animals that underwent the same procedure