Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Babcock et al., J Biol Chem 2013 : These findings indicate that the induction of ATF4/CHOP expression occurs via mTORC1 regulation of c-MYC and that this signaling pathway is a major determinant in the ability of bortezomib to induce apoptosis
Narisawa-Saito et al., Carcinogenesis 2012 (Cell Transformation, Neoplastic) : An mTOR inhibitor ( Rapamycin ) and MYC inhibition a level not affecting proliferation in culture both markedly suppressed tumor formation by HCKs expressing E6E7 and HRAS ( G12V )
Shepherd et al., Leukemia 2013 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Tan et al., Cancer Cell 2010 (Cell Transformation, Neoplastic...) : On loss of PPP2R2B, mTORC1 inhibitor rapamycin triggers a compensatory Myc phosphorylation in PDK1 dependent, but PI3K and AKT independent manner, resulting in resistance
Gustafson et al., Oncogene 2010 : Phosphorylation of Myc proteins is controlled in-part by the receptor tyrosine kinase/phosphatidylinositol 3-kinase/Akt/mTOR signaling , with additional contributions from Aurora A kinase
Rodrik et al., Mol Cell Biol 2005 (Breast Neoplasms) : These data provide evidence that E2 promotes survival signals in breast cancer cells through an mTOR dependent increase in Myc expression