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CDKN1A — NAB2

Text-mined interactions from Literome

Dai et al., Cell cycle (Georgetown, Tex.) 2003 : Finally, the NF-kappaB inhibitor CAPE antagonized NaB- and PMA related NF-kappaB DNA binding as well as induction of p21CIP1 ... Together, these findings suggest that NF-kappaB plays an important functional role in mediating NaB induced p21CIP1 induction, G1 arrest, and maturation in human myelomonocytic leukemia cells, and that disruption of the NF-kappaB pathway causes cells to engage an alternative, apoptotic program
Kobayashi et al., Nutr Cancer 2003 (Adenocarcinoma...) : In all cell lines, p21 mRNA levels were immediately elevated after NaB exposure, and p21 protein levels were increased within 6 h. NaB increased p21 promoter activity in both Caco2 and Lovo, suggesting p53 independence
Li et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2004 (Myelodysplastic Syndromes) : The results showed that NaB and/or ATRA blocked cells mainly in the G0/G1 phase of the cell cycle ; ATRA inhibited the mRNA expression of CDK6, CDK4, cyclin D3 and cyclin D1 ; NaB inhibited the mRNA expression of CDK2, cyclin D2 and cyclin D1 ; ATRA and NaB inhibited the mRNA expression of CDK6, CDK4, CDK2, cyclin D1, cyclin D2 and cyclin D3 ; ATRA and/or NaB both stimulated p21 expression at the mRNA levels
Khasnavis et al., J Neuroimmune Pharmacol 2012 (Parkinson Disease) : Together, these results suggest that NaB upregulates DJ-1 via modulation of mevalonate metabolites and that p21(ras), but not p21 ( rac ), is involved in the regulation of DJ-1
Qu et al., J Cell Biol 1998 : Furthermore, NAB2 overexpression led to downregulation of p21 ( WAF1 ), a molecule previously shown to play a pivotal role in the ability of PC12 cells to undergo growth arrest and commit to differentiation in response to NGF