Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Brugarolas et al., Genes Dev 2004 (Anoxia) : Here we show that mTOR inhibition by hypoxia requires the TSC1/TSC2 tumor suppressor complex and the hypoxia-inducible gene REDD1/RTP801
Nishioka et al., Int J Cancer 2009 (Leukemia, Myeloid, Acute) : ATRA ( 0.1-1 microM ) upregulated levels of RTP801 , a negative regulator of mTORC1, and inhibited mTORC1 signaling as assessed by measurement of the levels of p-p70S6K and p-4E-BP1 in HL60 and NB4 cells
Yoshida et al., Nat Med 2010 (Pulmonary Emphysema) : Rtp801 ( also known as Redd1, and encoded by Ddit4 ), a stress related protein triggered by adverse environmental conditions, inhibits mammalian target of rapamycin (mTOR) by stabilizing the TSC1-TSC2 inhibitory complex and enhances oxidative stress dependent cell death
Malagelada et al., J Neurosci 2011 : Here, we show that expression of RTP801/REDD1 , an inhibitor of mTOR ( mammalian target of rapamycin ) activation, is regulated during neuronal differentiation and that RTP801 functions to influence the timing of both neurogenesis and neuron migration
Molitoris et al., J Biol Chem 2011 : In support of this hypothesis, RNAi mediated suppression of Dig2/RTP801/REDD1 reduces mTOR inhibition and autophagy in glucocorticoid treated lymphocytes