Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Kristof et al., J Biol Chem 2003 (Inflammation) : The role of mTOR and PI3K in the activation of human inducible nitric oxide synthase transcription by cytokines and lipopolysaccharide (LPS) was investigated in lung epithelial adenocarcinoma ( A549 ) cells
Dello Russo et al., Biochem Pharmacol 2009 : Moreover, mTOR inhibitors reduced NOS activity and NOS2 expression induced by cytokines, but not those induced by LPS
Gibbs et al., Int J Biochem Cell Biol 2012 (Congenital Disorders of Glycosylation...) : Furthermore, we observed that nitric oxide synthase activity was dependent on mTOR in these myeloid cells and involved in HIF-1a accumulation mediated by endosomal toll-like receptor 7/8 triggering in THP-1 cells as well as IgE dependent basophil, but not mast cell, responses
Jaba et al., J Clin Invest 2013 : NOS inhibitor L-NAME also significantly attenuated RGS4 degradation, and reduced activation of AKT/mTORC1 signaling and induction of myocardial hypertrophy in PlGF transgenic mice, while conditional cardiac-specific PlGF expression in eNOS knockout mice did not induce myocardial hypertrophy