Gene interactions and pathways from curated databases and text-mining

◀ Back to NFKB1

NFKB1 — NOS1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kim et al., Mol Cells 1999 : Octamer motif is required for the NF-kappaB mediated induction of the inducible nitric oxide synthase gene expression in RAW 264.7 macrophages
Du et al., Free Radic Biol Med 1999 : Generation of reactive oxygen intermediates, activation of NF-kappaB , and induction of apoptosis in human endothelial cells by glucose : role of nitric oxide synthase ?
Lee et al., J Biol Chem 2000 : Incubation of macrophages with PAO1 led to NF-kappaB dependent expression of inducible nitric-oxide synthase , COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function
D'Acquisto et al., Naunyn Schmiedebergs Arch Pharmacol 1999 (Disease Models, Animal...) : We studied the involvement of nuclear factor-kappaB (NF-kappaB) in the regulation of inducible nitric oxide synthase expression in carrageenin induced rat pleurisy
Pan et al., Biochem Pharmacol 2000 : Furthermore, geraniin, 5GG, and TF-3 all blocked phosphorylation of IKB from the cytosolic fraction, inhibited nuclear factor-kappaB (NFkappaB) activity, and inhibited increases in inducible nitric oxide synthase levels in activated macrophages
Stasiolek et al., J Biol Chem 2000 (Astrocytoma...) : Expression of inflammatory nitric oxide synthase ( NOS2 ) is mediated by transcription factor NFkappaB
Pahan et al., J Biol Chem 2001 : Induction of nitric-oxide synthase and activation of NF-kappaB by interleukin-12 p40 in microglial cells
Qu et al., FASEB J 2001 : We examined a new mechanism of intestinal iNOS regulation with respect to the role of nNOS and its effect on NF-kappaB ... We conclude that in normal rat small intestine, nNOS suppresses the gene expression of iNOS through NF-kappaB down-regulation and that nNOS suppression leads to IkappaBalpha degradation, NF-kappaB activation, and iNOS expression
Chan et al., Infect Immun 2001 : Induction of inducible nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is mediated by MEK1-ERK, MKK7-JNK, and NF-kappaB signaling pathways
Hatano et al., Gastroenterology 2001 : NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas mediated apoptosis
Ganster et al., Proc Natl Acad Sci U S A 2001 : Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B
Liu et al., J Cell Biochem 2001 : Distinct involvement of NF-kappaB and p38 mitogen activated protein kinase pathways in serum deprivation mediated stimulation of inducible nitric oxide synthase and its inhibition by 4-hydroxynonenal
Cho et al., Int Immunopharmacol 2002 : The effects of arctigenin and demethyltraxillagenin on the nuclear factor-kappaB (NF-kappaB) mediated inducible nitric oxide synthase ( iNOS, EC1.14.13.39 ) gene expression were studied in Raw264.7 cells
Tantini et al., FEBS Lett 2002 : Here we show an involvement of nuclear factor-kappaB (NF-kappaB) in the induction of nitric oxide synthase (NOS) and ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis
Wayman et al., FASEB J 2002 (Myocardial Infarction...) : Inhibition by 15D-PGJ2 of the activation of NF-kappaB in turn results in a reduction of the 1 ) expression of inducible nitric oxide synthase and the nitration of proteins by peroxynitrite, 2 ) formation of the chemokine MCP-1, and 3 ) expression of the adhesion molecule ICAM-1
Watanabe et al., Anticancer Res 2002 (Carcinoma, Squamous Cell...) : The induction of inducible nitric oxide synthase is regulated by nuclear-factor kappa B (NF-kappa B)
Neu et al., Biochem Pharmacol 2003 : TNF-alpha induced apoptosis of isolated parietal cells was inhibited by pretreatment with different NF-kappaB-inhibitors , nitric oxide synthase inhibitors and with antisense-oligodeoxynucleotides against the p65 subunit of NF-kappaB
Lee et al., Life Sci 2003 : The regulation of inducible nitric oxide synthase gene expression induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of AP-1 and NFkappaB
Han et al., J Pharmacol Exp Ther 2003 (Inflammation) : Treatment of cytomix stimulated cells with NAD+ also blocked nuclear factor-kappaB (NF-kappaB) activation, inducible nitric-oxide synthase induction , and increased production of nitric oxide ( NO. )
Attuwaybi et al., J Surg Res 2003 (Reperfusion Injury) : We have previously shown that regional intraischemic hypothermia ( IH ) protects against moderate gut I/R induced mucosal injury, is associated with decreased NF-kappaB activity and inducible nitric oxide synthase induction and preserves heme oxygenase-1 (HO-1) expression
Kumagai et al., J Biol Chem 2004 (Arteriosclerosis) : To understand the possible signaling mechanism underlying the inducing effect of HNE on COX-2 up-regulation, we examined the phosphorylation events that may lead to COX-2 induction and found that HNE did not stimulate the induction of nitric oxide synthase and activation of NF-kappaB but significantly activated p38 mitogen activated protein kinase and its upstream kinase in RAW264.7 macrophages
Jang et al., Biochem Pharmacol 2004 : Catalase induces the expression of inducible nitric oxide synthase through activation of NF-kappaB and PI3K signaling pathway in Raw 264.7 cells
Woo et al., Pharmacol Res 2005 : Amentoflavone inhibits the induction of nitric oxide synthase by inhibiting NF-kappaB activation in macrophages
Cho et al., Biochim Biophys Acta 2005 : BIC also induces nitric oxide synthase in macrophages through JunB/AP-1 and NF-kappaB activation
Davis et al., Nitric Oxide 2005 : Effects of mechanistically distinct NF-kappaB inhibitors on glial inducible nitric-oxide synthase expression
Muceniece et al., J Neuroimmunol 2005 (Disease Models, Animal...) : We found that beta-MSH suppresses LPS induced nuclear translocation of the transcription factor NF-kappaB , and inhibits the expression of inducible nitric oxide synthase , and the following nitric oxide overproduction in the brain, in vivo
Farhangkhoee et al., Nutrition & metabolism 2006 : Cultured MVECs, exposed either to glucose or glucose and varying concentrations of curcumin, were assessed for alterations of NOS expression and activation of nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1)
Nakata et al., Arterioscler Thromb Vasc Biol 2007 : Inhibition of NF-kappaB by dominant negative IkappaB also attenuated atorvastatin induced nNOS expression and NF-kappaB activation, but not Akt activation
Chan et al., J Physiol 2007 (Brain Death...) : Using a clinically relevant animal model that employed the organophosphate pesticide mevinphos ( Mev ) as the experimental insult, we evaluated the hypothesis that transcriptional up-regulation of nitric oxide synthase I or II ( NOS I or II ) gene expression by nuclear factor-kappaB (NF-kappaB) on activation of muscarinic receptors in the RVLM underlies brain stem death
Fan et al., Life Sci 2007 (Cardiomyopathies...) : In addition, it was found that NF-kappaB was activated by AVP, and that PDTC could inhibit NO production, NOS activity, protein and mRNA levels of iNOS stimulated by AVP in a dose dependent manner
Choi et al., Eur J Pharmacol 2007 : Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB , ERK1/2, and p38 kinase
Zhang et al., Am J Pathol 2007 (Brain Ischemia...) : In conclusion, our results demonstrate that after MCAO the interaction between tPA and LRP results in NF-kappaB activation in astrocytes and induction of inducible nitric-oxide synthase expression in the ischemic tissue, suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia
Jones et al., Journal of inflammation (London, England) 2007 : NF-kappaB activation upregulates inducible nitric oxide synthase leading to enhanced nitric oxide production during an inflammatory response
Tjalkens et al., J Neurosci Res 2008 : Because NF-kappaB dependent expression of inducible nitric oxide synthase ( NOS2 ) can be antagonized by the nuclear orphan receptor peroxisome proliferator activated receptor-gamma ( PPARgamma ), we postulated that a novel agonist of this receptor, 1,1-bis ( 3'-indolyl ) -1- ( p-trifluoromethylphenyl ) methane ( cDIM1 ), would suppress expression of NOS2 in astrocytes and protect cocultured neuronal cells from apoptosis
Kim et al., Mol Pharmacol 2008 (Inflammation...) : BOT-64 attenuates NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase , cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Prabhakaran et al., Brain Res Bull 2008 (Manganese Poisoning...) : These findings suggest that NF-kappaB induction and the activation of nitric oxide synthase through ROS represent a proximate mechanism for Mn-induced neurotoxicity
Carbone et al., Brain Res 2008 (Inflammation...) : A role for NF-kappaB in MPTP dependent induction of NOS1 was confirmed through overexpression of a mutant IkappaBalpha super repressor of NF-kappaB that prevented induction of NOS1 ... The data presented here thus demonstrate a role for NF-kappaB in selective induction of NOS1 during early inflammatory activation of astrocytes stimulated by low-dose MPTP and inflammatory cytokines
Carbone et al., Mol Pharmacol 2009 : The data presented here demonstrate the efficacy of a novel anti-inflammatory diindolylmethane class compound, 1,1-bis ( 3'-indolyl ) -1- ( p-t-butylphenyl ) methane ( DIM-C-pPhtBu ), in suppressing NF-kappaB dependent expression of inducible nitric-oxide synthase ( NOS2 ) and NO production in astrocytes exposed to the parkinsonian neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) through a mechanism distinct from that described for the thiazolidinedione-class compound, rosiglitazone
Jin et al., J Pain 2009 (Neuralgia) : Variants of neural nitric oxide synthase in the spinal cord of neuropathic rats and their effects on nuclear factor-kappaB (NF-kappaB) activity in PC12 cells
Du et al., Cancer Res 2009 (Neoplasms) : The human inducible nitric oxide synthase ( hiNOS ) gene is regulated by nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway
de Mejia et al., Peptides 2009 (Inflammation) : The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ), nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Lee et al., J Pharmacol Sci 2009 (Neurotoxicity Syndromes) : Moreover, ISL impeded the expression of nitric oxide synthase and the activation of NF-kappaB through blockage of its phosphorylation
Dahlman et al., J Biol Chem 2010 : Together, these data broaden our understanding of NF-kappaB during development by showing that in addition to its role as a negative regulator of myogenesis, NF-kappaB also regulates nitric-oxide synthase expression within stromal fibroblasts to stimulate myoblast fusion and muscle hypertrophy
Hseu et al., Food Chem Toxicol 2010 : In an earlier study, we found that Antrodia camphorata inhibited the production of lipopolysaccharide (LPS) induced cytokines, inducible nitric oxide synthase , and cyclooxygenase-2 by blocking nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages
Simko et al., J Hypertens 2010 (Hypertension) : Inhibition of nuclear factor kappa B (NF-kappaB) potentiates hypertension development, enhances oxidative load, increases the cross-sectional area of the aorta and reduces nitric oxide ( NO ) synthase activity in L-NAME hypertension
Oussaief et al., J Virol 2011 : NF-kappaB mediated modulation of inducible nitric oxide synthase activity controls induction of the Epstein-Barr virus productive cycle by transforming growth factor beta 1
Patruno et al., Biochim Biophys Acta 2012 (Inflammation) : These results suggest that LPS regulates the opposite NOS expression in H9c2 cells by modifying the redox state of these cells responsible for the NF-kB nuclear translocation via NIK-IKKa/ß-IkBa, simultaneous to the inactivation of the PI3K/Akt pathway
Hwang et al., Nitric Oxide 2013 : Glucosamine inhibits lipopolysaccharide stimulated inducible nitric oxide synthase induction by inhibiting expression of NF-kappaB/Rel proteins at the mRNA and protein levels
Kone et al., Am J Physiol 1995 : Role of NF-kappa B in the regulation of inducible nitric oxide synthase in an MTAL cell line
Xie et al., J Biol Chem 1994 : Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase
Nishiya et al., FEBS Lett 1995 (Glioma) : Herbimycin A suppresses NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent induction of nitric oxide synthase in C6 glioma cells
Kleinert et al., J Biol Chem 1996 (Second Messenger Systems) : Transcription factor NF-kappaB is essential for the induction of nitric oxide synthase (NOS) II ( iNOS ) by bacterial lipopolysaccharide in murine macrophages ( Xie, Q. W., Kashiwabara, Y., and Nathan, C. ( 1994 ) J. Biol. Chem. 269, 4705-4708 )
Park et al., Biochem J 1997 : Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-kappaB binding to DNA
Wong et al., Biochem Biophys Res Commun 1997 : The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I kappa-B degradation and NF-kappa B nuclear translocation
Togashi et al., Proc Natl Acad Sci U S A 1997 : Our data suggest that nNOS in astrocytes regulates NF kappaB activity and iNOS expression, and indicate a novel regulatory role for nNOS in tonically suppressing central nervous system, NF kappaB regulated genes
Lee et al., Biochem J 1997 : NF-kappaB dependent expression of nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts ... These results suggest that NF-kappaB dependent expression of NOS is an important step in membrane fusion of chick embryonic myoblasts
Spitsin et al., Mol Med 1997 : Human- and mouse-inducible nitric oxide synthase promoters require activation of phosphatidylcholine-specific phospholipase C and NF-kappa B ... Additionally, NF-kappa B activation is necessary but not sufficient for inducible nitric oxide synthase production in human cells, in contrast to murine cells in which it serves as a complete inducer
Heitmeier et al., J Biol Chem 1998 : Double stranded RNA induced inducible nitric-oxide synthase expression and interleukin-1 release by murine macrophages requires NF-kappaB activation
Marks-Konczalik et al., J Biol Chem 1998 : The involvement of AP-1 and NF-kappaB transcription factors in cytokine mediated induction of human inducible nitric oxide synthase ( hiNOS ) promoter activity was examined
D'Acquisto et al., Eur J Pharmacol 1999 : We studied the role of nuclear factor-kappaB (NF-kappaB) on the tone and on the expression of inducible nitric oxide (NO) synthase , both evaluated in aortas from lipopolysaccharide treated rats