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NFKB1 — NOS1
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
Gene Ontology Complexes protein complex:
protein complex complex (HSF1-TRMT112-HIST1H4A-UBQLN1-CDX2-USP28-HDAC5-CAV3-CANX-LHX1-TUBA3C-TUBA3E-PI4K2A-NR0B2-RYR2-NTRK1-MPP5-N6AMT1-STAP1-ZFP42-FADD-ATP6V0D1-PRKCDBP-AQP2-FNTB-PRPSAP2-WIPI2-CRB3-CRB2-PEX11A-LDB1-RBP4-TMEM102-GATA2-ADCY2-DZIP1-SYK-TUBB4B-PTPN11-KAT5-CEP290-SYP-ASF1B-PLEKHA2-KIF24-MYO5B-RGP1-CFTR-SPTBN5-VPS72-ACTA2-PRKCI-CNST-SNX4-GNAO1-NFKBIA-UBE2D2-EPB41-RAB5A-GLUL-BSND-GSK3B-SKI-XRCC6-PPM1E-TTR-TUBA1A-SUCLG1-TRIAP1-AKT1S1-MYD88-NPPB-GDF11-INCENP-PLCB3-BECN1-PRKAB1-SOD1-TUBB1-NPHS2-NPHS1-EPS8L1-GDI1-TUBB2A-TUBB2B-SUCLG2-PEX3-TUBAL3-ERLIN1-MAGED1-GCH1-TUBB-CPS1-MEF2C-ZNF703-SLC22A6-CPLX1-EIF4EBP1-TUBE1-FLNA-CD19-STX1A-HDAC2-TOMM40L-HDAC6-SMAD6-SMAD7-TLE6-SMAD2-PARD6B-STXBP1-ACR-TRPC1-PARD6A-TRPC4-PANX1-DCTN1-SOX9-PXMP2-BCR-SET-MALT1-BHMT-RILP-TRADD-HIST1H3A-MAPK1-PVALB-NFKB1-NUFIP1-ACVR2B-TAL1-FOXP3-SSX2IP-GNB2-SLC27A5-GOPC-PAX2-CXADR-AIF1L-APBA1-MYL12A-LMO2-ID2-CCDC113-DDOST-SPP2-GATAD2B-PLN-ERCC8-BIRC8-ASF1A-CAB39-BIRC3-BIRC2-CTNNB1-CORO1A-PRELID1-HAND2-CHAF1B-SCAP-GNAT3-CDC20-SMARCA4-IQGAP1-YWHAZ-CEBPA-PRPS2-AXIN1-XRCC5-YWHAQ-UVRAG-SLC51B-RGS4-RGS6-HTT-YWHAB-APCS-CDCA8-RIPK1-MTA2-SIN3A-ANXA1-NOS1-SNTA1-TRAF6-KPNB1-VCL-VCP-PTRF-PRKCZ-SKIL-RAB3A-KRIT1-SSBP3-PRPSAP1-PPP1CC-TAB1-MYO6-ACTL7A-TUBG2-MBD2-COL6A1-COL6A2-BCL3)
Helps et al., Biochem J 2000, Lauderdale et al., Proc Natl Acad Sci U S A 2000, Didichenko et al., FEBS Lett 2000, Koh et al., Curr Biol 2002, Fan et al., Mol Cell Biol 2002, Groisman et al., Cell 2003, Offenhäuser et al., Mol Biol Cell 2004, Tagami et al., Cell 2004, Doyon et al., Mol Cell Biol 2004, Moore et al., Genomics 2004, Sun et al., Mol Cell 2004, Zang et al., J Cell Biochem 2004, Tian et al., Cancer Res 2005, An et al., Biochemistry 2005, Mahajan et al., Proc Natl Acad Sci U S A 2005, Vader et al., EMBO Rep 2006, Yeh et al., J Biol Chem 2006, Li et al., Immunol Rev 2006, Agbas et al., Biochem J 2007, Swiatecka-Urban et al., J Biol Chem 2007, McKeegan et al., Mol Cell Biol 2007, Shono et al., J Am Soc Nephrol 2007, Popov et al., Cell cycle (Georgetown, Tex.) 2007, Sato et al., J Biol Chem 2008, Fitzgerald et al., J Biol Chem 2008, Lyssand et al., J Biol Chem 2008, Figaro et al., FEBS Lett 2008, Ueda et al., Proc Natl Acad Sci U S A 2008, Shimojo et al., J Biol Chem 2008, Costantini et al., Blood 2009, Mitsuishi et al., J Biol Chem 2010, Masuda et al., J Biol Chem 2010, Koch et al., J Cell Sci 2010, Boëda et al., J Biol Chem 2011, Sircoulomb et al., EMBO Mol Med 2011, Hoxhaj et al., J Cell Sci 2012, Uckun et al., Proc Natl Acad Sci U S A 2012, Pusapati et al., J Biol Chem 2012, Ghai et al., Proc Natl Acad Sci U S A 2013, Kelly et al., PLoS Biol 2013, Chiang et al., PloS one 2013, Dauphinee et al., J Immunol 2013, Potting et al., Cell Metab 2013, Ludwig et al., PLoS Biol 2013, Lee et al., Proc Natl Acad Sci U S A 2013, Kobayashi et al., J Cell Biol 2014, Zheng et al., Am J Physiol 1994, Kumar et al., Biochem Biophys Res Commun 1998, Watabe-Uchida et al., J Cell Biol 1998, Haft et al., Mol Cell Biol 1998
Text-mined interactions from Literome
Kim et al., Mol Cells 1999
:
Octamer motif is required for the
NF-kappaB mediated induction of the inducible
nitric oxide synthase gene expression in RAW 264.7 macrophages
Du et al., Free Radic Biol Med 1999
:
Generation of reactive oxygen intermediates,
activation of
NF-kappaB , and induction of apoptosis in human endothelial cells by glucose : role of
nitric oxide synthase ?
Lee et al., J Biol Chem 2000
:
Incubation of macrophages with PAO1 led to
NF-kappaB dependent expression of inducible
nitric-oxide synthase , COX-2, and tumor necrosis factor-alpha, which was unaffected by inhibition of Rac1 or Cdc42 function
D'Acquisto et al., Naunyn Schmiedebergs Arch Pharmacol 1999
(Disease Models, Animal...) :
We studied the
involvement of
nuclear factor-kappaB (NF-kappaB) in the regulation of inducible
nitric oxide synthase expression in carrageenin induced rat pleurisy
Pan et al., Biochem Pharmacol 2000
:
Furthermore, geraniin, 5GG, and TF-3 all blocked phosphorylation of IKB from the cytosolic fraction, inhibited
nuclear factor-kappaB (NFkappaB) activity, and
inhibited increases in inducible
nitric oxide synthase levels in activated macrophages
Stasiolek et al., J Biol Chem 2000
(Astrocytoma...) :
Expression of inflammatory
nitric oxide synthase ( NOS2 ) is
mediated by transcription factor
NFkappaB
Pahan et al., J Biol Chem 2001
:
Induction of
nitric-oxide synthase and
activation of
NF-kappaB by interleukin-12 p40 in microglial cells
Qu et al., FASEB J 2001
:
We examined a new mechanism of intestinal iNOS regulation with respect to the role of
nNOS and its
effect on
NF-kappaB ... We conclude that in normal rat small intestine, nNOS suppresses the gene expression of iNOS through NF-kappaB down-regulation and that
nNOS suppression
leads to IkappaBalpha degradation,
NF-kappaB activation, and iNOS expression
Chan et al., Infect Immun 2001
:
Induction of inducible
nitric oxide synthase-NO* by lipoarabinomannan of Mycobacterium tuberculosis is
mediated by MEK1-ERK, MKK7-JNK, and
NF-kappaB signaling pathways
Hatano et al., Gastroenterology 2001
:
NF-kappaB stimulates inducible
nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas mediated apoptosis
Ganster et al., Proc Natl Acad Sci U S A 2001
:
Complex
regulation of human inducible
nitric oxide synthase gene transcription by Stat 1 and
NF-kappa B
Liu et al., J Cell Biochem 2001
:
Distinct involvement of
NF-kappaB and p38 mitogen activated protein kinase pathways in serum deprivation
mediated stimulation of inducible
nitric oxide synthase and its inhibition by 4-hydroxynonenal
Cho et al., Int Immunopharmacol 2002
:
The effects of arctigenin and demethyltraxillagenin on the
nuclear factor-kappaB (NF-kappaB) mediated inducible
nitric oxide synthase ( iNOS, EC1.14.13.39 ) gene expression were studied in Raw264.7 cells
Tantini et al., FEBS Lett 2002
:
Here we show an
involvement of
nuclear factor-kappaB (NF-kappaB) in the induction of
nitric oxide synthase (NOS) and ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis
Wayman et al., FASEB J 2002
(Myocardial Infarction...) :
Inhibition by 15D-PGJ2 of the activation of
NF-kappaB in turn
results in a reduction of the 1 ) expression of inducible
nitric oxide synthase and the nitration of proteins by peroxynitrite, 2 ) formation of the chemokine MCP-1, and 3 ) expression of the adhesion molecule ICAM-1
Watanabe et al., Anticancer Res 2002
(Carcinoma, Squamous Cell...) :
The induction of inducible
nitric oxide synthase is
regulated by
nuclear-factor kappa B (NF-kappa B)
Neu et al., Biochem Pharmacol 2003
:
TNF-alpha induced apoptosis of isolated parietal cells was inhibited by pretreatment with different
NF-kappaB-inhibitors ,
nitric oxide synthase inhibitors and with antisense-oligodeoxynucleotides against the p65 subunit of NF-kappaB
Lee et al., Life Sci 2003
:
The regulation of inducible
nitric oxide synthase gene expression
induced by lipopolysaccharide and tumor necrosis factor-alpha in C6 cells : involvement of AP-1 and
NFkappaB
Han et al., J Pharmacol Exp Ther 2003
(Inflammation) :
Treatment of cytomix stimulated cells with NAD+ also blocked
nuclear factor-kappaB (NF-kappaB) activation, inducible
nitric-oxide synthase induction , and increased production of nitric oxide ( NO. )
Attuwaybi et al., J Surg Res 2003
(Reperfusion Injury) :
We have previously shown that regional intraischemic hypothermia ( IH ) protects against moderate gut I/R induced mucosal injury, is associated with decreased
NF-kappaB activity and inducible
nitric oxide synthase induction and preserves heme oxygenase-1 (HO-1) expression
Kumagai et al., J Biol Chem 2004
(Arteriosclerosis) :
To understand the possible signaling mechanism underlying the inducing effect of HNE on COX-2 up-regulation, we examined the phosphorylation events that may lead to COX-2 induction and found that HNE did not stimulate the induction of
nitric oxide synthase and
activation of
NF-kappaB but significantly activated p38 mitogen activated protein kinase and its upstream kinase in RAW264.7 macrophages
Jang et al., Biochem Pharmacol 2004
:
Catalase
induces the expression of inducible
nitric oxide synthase through activation of
NF-kappaB and PI3K signaling pathway in Raw 264.7 cells
Woo et al., Pharmacol Res 2005
:
Amentoflavone
inhibits the induction of
nitric oxide synthase by inhibiting
NF-kappaB activation in macrophages
Cho et al., Biochim Biophys Acta 2005
:
BIC also
induces nitric oxide synthase in macrophages through JunB/AP-1 and
NF-kappaB activation
Davis et al., Nitric Oxide 2005
:
Effects of mechanistically distinct
NF-kappaB inhibitors on glial inducible
nitric-oxide synthase expression
Muceniece et al., J Neuroimmunol 2005
(Disease Models, Animal...) :
We found that beta-MSH suppresses LPS induced nuclear translocation of the transcription factor
NF-kappaB , and
inhibits the expression of inducible
nitric oxide synthase , and the following nitric oxide overproduction in the brain, in vivo
Farhangkhoee et al., Nutrition & metabolism 2006
:
Cultured MVECs, exposed either to glucose or glucose and varying concentrations of curcumin, were assessed for alterations of
NOS expression and
activation of
nuclear factor-kappaB (NF-kappaB) and activating protein-1 (AP-1)
Nakata et al., Arterioscler Thromb Vasc Biol 2007
:
Inhibition of
NF-kappaB by dominant negative IkappaB also
attenuated atorvastatin induced
nNOS expression and NF-kappaB activation, but not Akt activation
Chan et al., J Physiol 2007
(Brain Death...) :
Using a clinically relevant animal model that employed the organophosphate pesticide mevinphos ( Mev ) as the experimental insult, we evaluated the hypothesis that transcriptional
up-regulation of
nitric oxide synthase I or II ( NOS I or II ) gene expression by
nuclear factor-kappaB (NF-kappaB) on activation of muscarinic receptors in the RVLM underlies brain stem death
Fan et al., Life Sci 2007
(Cardiomyopathies...) :
In addition, it was found that
NF-kappaB was activated by AVP, and that PDTC could
inhibit NO production,
NOS activity, protein and mRNA levels of iNOS stimulated by AVP in a dose dependent manner
Choi et al., Eur J Pharmacol 2007
:
Isoeugenol suppression of inducible
nitric oxide synthase expression is
mediated by down-regulation of
NF-kappaB , ERK1/2, and p38 kinase
Zhang et al., Am J Pathol 2007
(Brain Ischemia...) :
In conclusion, our results demonstrate that after MCAO the interaction between tPA and LRP results in
NF-kappaB activation in astrocytes and
induction of inducible
nitric-oxide synthase expression in the ischemic tissue, suggesting a cytokine-like plasminogen independent role for tPA during cerebral ischemia
Jones et al., Journal of inflammation (London, England) 2007
:
NF-kappaB activation
upregulates inducible
nitric oxide synthase leading to enhanced nitric oxide production during an inflammatory response
Tjalkens et al., J Neurosci Res 2008
:
Because
NF-kappaB dependent expression of inducible
nitric oxide synthase ( NOS2 ) can be antagonized by the nuclear orphan receptor peroxisome proliferator activated receptor-gamma ( PPARgamma ), we postulated that a novel agonist of this receptor, 1,1-bis ( 3'-indolyl ) -1- ( p-trifluoromethylphenyl ) methane ( cDIM1 ), would suppress expression of NOS2 in astrocytes and protect cocultured neuronal cells from apoptosis
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
BOT-64 attenuates
NF-kappaB regulated expression of inflammatory genes such as inducible
nitric-oxide synthase , cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Prabhakaran et al., Brain Res Bull 2008
(Manganese Poisoning...) :
These findings suggest that
NF-kappaB induction and the
activation of
nitric oxide synthase through ROS represent a proximate mechanism for Mn-induced neurotoxicity
Carbone et al., Brain Res 2008
(Inflammation...) :
A
role for
NF-kappaB in MPTP dependent induction of
NOS1 was confirmed through overexpression of a mutant IkappaBalpha super repressor of NF-kappaB that prevented induction of NOS1 ... The data presented here thus demonstrate a
role for
NF-kappaB in selective induction of
NOS1 during early inflammatory activation of astrocytes stimulated by low-dose MPTP and inflammatory cytokines
Carbone et al., Mol Pharmacol 2009
:
The data presented here demonstrate the efficacy of a novel anti-inflammatory diindolylmethane class compound, 1,1-bis ( 3'-indolyl ) -1- ( p-t-butylphenyl ) methane ( DIM-C-pPhtBu ), in suppressing
NF-kappaB dependent expression of inducible
nitric-oxide synthase ( NOS2 ) and NO production in astrocytes exposed to the parkinsonian neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine ( MPTP ) through a mechanism distinct from that described for the thiazolidinedione-class compound, rosiglitazone
Jin et al., J Pain 2009
(Neuralgia) :
Variants of neural
nitric oxide synthase in the spinal cord of neuropathic rats and their
effects on
nuclear factor-kappaB (NF-kappaB) activity in PC12 cells
Du et al., Cancer Res 2009
(Neoplasms) :
The human inducible
nitric oxide synthase ( hiNOS ) gene is
regulated by
nuclear factor kappaB (NF-kappaB) and has recently been shown to be a target of the Wnt/beta-catenin pathway
de Mejia et al., Peptides 2009
(Inflammation) :
The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ), interleukin-1beta production ( IC ( 50 ) =13 microM ),
nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible
nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Lee et al., J Pharmacol Sci 2009
(Neurotoxicity Syndromes) :
Moreover, ISL impeded the expression of
nitric oxide synthase and the
activation of
NF-kappaB through blockage of its phosphorylation
Dahlman et al., J Biol Chem 2010
:
Together, these data broaden our understanding of NF-kappaB during development by showing that in addition to its role as a negative regulator of myogenesis,
NF-kappaB also
regulates nitric-oxide synthase expression within stromal fibroblasts to stimulate myoblast fusion and muscle hypertrophy
Hseu et al., Food Chem Toxicol 2010
:
In an earlier study, we found that Antrodia camphorata
inhibited the production of lipopolysaccharide (LPS) induced cytokines, inducible
nitric oxide synthase , and cyclooxygenase-2 by blocking
nuclear factor-kappaB (NF-kappaB) activation in cultured RAW 264.7 macrophages
Simko et al., J Hypertens 2010
(Hypertension) :
Inhibition of
nuclear factor kappa B (NF-kappaB) potentiates hypertension development, enhances oxidative load, increases the cross-sectional area of the aorta and
reduces nitric oxide ( NO ) synthase activity in L-NAME hypertension
Oussaief et al., J Virol 2011
:
NF-kappaB mediated modulation of inducible
nitric oxide synthase activity controls induction of the Epstein-Barr virus productive cycle by transforming growth factor beta 1
Patruno et al., Biochim Biophys Acta 2012
(Inflammation) :
These results suggest that LPS
regulates the opposite
NOS expression in H9c2 cells by modifying the redox state of these cells responsible for the
NF-kB nuclear translocation via NIK-IKKa/ß-IkBa, simultaneous to the inactivation of the PI3K/Akt pathway
Hwang et al., Nitric Oxide 2013
:
Glucosamine
inhibits lipopolysaccharide stimulated inducible
nitric oxide synthase induction by inhibiting expression of
NF-kappaB/Rel proteins at the mRNA and protein levels
Kone et al., Am J Physiol 1995
:
Role of
NF-kappa B in the regulation of inducible
nitric oxide synthase in an MTAL cell line
Xie et al., J Biol Chem 1994
:
Role of transcription factor
NF-kappa B/Rel in induction of
nitric oxide synthase
Nishiya et al., FEBS Lett 1995
(Glioma) :
Herbimycin A suppresses
NF-kappa B activation and tyrosine phosphorylation of JAK2 and the subsequent
induction of
nitric oxide synthase in C6 glioma cells
Kleinert et al., J Biol Chem 1996
(Second Messenger Systems) :
Transcription factor
NF-kappaB is
essential for the induction of
nitric oxide synthase (NOS) II ( iNOS ) by bacterial lipopolysaccharide in murine macrophages ( Xie, Q. W., Kashiwabara, Y., and Nathan, C. ( 1994 ) J. Biol. Chem. 269, 4705-4708 )
Park et al., Biochem J 1997
:
Nitric oxide
regulates nitric oxide synthase-2 gene expression by inhibiting
NF-kappaB binding to DNA
Wong et al., Biochem Biophys Res Commun 1997
:
The heat shock response
inhibits inducible
nitric oxide synthase gene expression by blocking I kappa-B degradation and
NF-kappa B nuclear translocation
Togashi et al., Proc Natl Acad Sci U S A 1997
:
Our data suggest that
nNOS in astrocytes
regulates NF kappaB activity and iNOS expression, and indicate a novel regulatory role for nNOS in tonically suppressing central nervous system, NF kappaB regulated genes
Lee et al., Biochem J 1997
:
NF-kappaB dependent expression of
nitric oxide synthase is required for membrane fusion of chick embryonic myoblasts ... These results suggest that
NF-kappaB dependent expression of
NOS is an important step in membrane fusion of chick embryonic myoblasts
Spitsin et al., Mol Med 1997
:
Human- and mouse-inducible
nitric oxide synthase promoters
require activation of phosphatidylcholine-specific phospholipase C and
NF-kappa B ... Additionally,
NF-kappa B activation is
necessary but not sufficient for inducible
nitric oxide synthase production in human cells, in contrast to murine cells in which it serves as a complete inducer
Heitmeier et al., J Biol Chem 1998
:
Double stranded RNA induced inducible
nitric-oxide synthase expression and interleukin-1 release by murine macrophages
requires NF-kappaB activation
Marks-Konczalik et al., J Biol Chem 1998
:
The
involvement of AP-1 and
NF-kappaB transcription factors in cytokine mediated induction of human inducible
nitric oxide synthase ( hiNOS ) promoter activity was examined
D'Acquisto et al., Eur J Pharmacol 1999
:
We studied the
role of
nuclear factor-kappaB (NF-kappaB) on the tone and on the expression of inducible
nitric oxide (NO) synthase , both evaluated in aortas from lipopolysaccharide treated rats