Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Shepherd et al., Leukemia 2013 (Precursor T-Cell Lymphoblastic Leukemia-Lymphoma) : PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response
Pajvani et al., Nat Med 2013 (Body Weight...) : We demonstrate that Notch signaling increases mTorc1 complex stability, augmenting mTorc1 function and sterol regulatory element binding transcription factor 1c ( Srebp1c ) -mediated lipogenesis