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MET — NOX4
Text-mined interactions from Literome
Park et al., Biochem J 2001
:
In addition, 5,6-dichloro-1-beta-o-ribofuranosyl benzimidazole, a CK2 inhibitor, potentiates
formyl-Met-Leu-Phe induced
NADPH oxidase activity in DMSO differentiated HL-60 cells
Ammendola et al., Free Radic Biol Med 2004
:
We investigated in IMR90 cells the
effects of
N-formyl-Met-Leu-Phe ( N-fMLP ) and WKYMVm ( W peptide ) on activation of the
NADPH oxidase-like enzyme
Tyagi et al., Antioxid Redox Signal 2009
:
Met increased
NADPH-oxidase-4 (NOX-4) expression and mitigated thioredxion-1(Trx-1) expression
Volk et al., J Innate Immun 2011
(MAP Kinase Signaling System...) :
PMN generated reactive oxygen species ( ROS ) in response to TNF-a alone, and
NADPH oxidase activity increased in
response to stimulation with
formyl-Met-Leu-Phe after priming
Thelen et al., J Clin Invest 1988
:
It thus appears that
f-Met-Leu-Phe can
lead to maximum activation of the
NADPH-oxidase , and that this response is not influenced by IFN gamma