Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Ropelle et al., Diabetes 2008 (Weight Loss) : Leucine and HPD decrease AMPK and increase mTOR activity in the hypothalamus, leading to inhibition of neuropeptide Y and stimulation of pro-opiomelanocortin expression
Shimizu et al., Peptides 2010 : In this study, we examined whether the mTOR signaling in the hypothalamus is involved in the regulation of neuropeptide Y (Npy) gene expression in the arcuate nucleus by glucocorticoids