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NPY — PRL
Text-mined interactions from Literome
García et al., FASEB J 2003
(Hyperphagia...) :
Hypothalamic levels of
NPY , MCH, and prepro-orexin mRNA during pregnancy and lactation in the rat :
role of
prolactin
Hurley et al., Endocrinology 2003
(Dwarfism, Pituitary) :
The reduction in total NPY mRNA was greater than that reported in studies of GH-deficient rats, suggesting that
NPY expression may be
affected by the lifelong absence of
prolactin or TSH or both, as well as GH
Chen et al., Endocrinology 2004
:
In the present study, we investigated the
role of
prolactin (PRL) in the suckling induced increase in hypothalamic
neuropeptide Y (NPY) gene expression in the dorsomedial nucleus of the hypothalamus ( DMH ) and the caudal portion of the arcuate nucleus of the hypothalamus ( ARH-C )
Hill et al., Endocrinology 2004
:
In addition,
NPY inhibited
prolactin secretion from primary pituitary cells in a steroid-free environment, but not in the presence of estrogen
Arumugam et al., Endocrinology 2007
(Insulinoma...) :
Pharmacological inhibition of AMPK activity blunted slightly the
effects of
PRL on
NPY and CART but reversed entirely the effects of Dex or of PRL plus Dex on CART mRNA ... The
effects of
PRL on
NPY , CART, and AMPK mRNA were mirrored by those of other lactogens and somatogens including placental lactogen and GH
Roy et al., J Endocrinol 2007
:
Prolactin (PRL) induces the expression of orexigenic
neuropeptide Y (NPY) through the activation of JAK-2/STAT-3 signaling pathway in hypothalamic paraventricular nucleus ( PVN ) leading to hyperphagia
Ghosh et al., Endocrinology 1991
:
The results suggest that
NPY plays a physiological role in the control of gonadotropin and
PRL release in the adult male mouse, and that expression of the bGH gene in transgenic mice is associated with altered role of endogenous NPY in the control of pituitary function
Härfstrand et al., Neurochem Int 1986
:
( 5 ) In the intraventricular experiments reported above
neuropeptide Y ( 1.25 nmol, 1 h )
reduced the serum levels of thyreotropin stimulating hormone,
prolactin and luteinizing hormone and increased serum corticosterone, adrenocorticotrophin, vasopressin, angiotensin II and aldosterone levels ... The present morphological, neurochemical and functional studies indicate that
neuropeptide Y given intraventricularly
inhibit the secretion of
prolactin , luteinizing and thyreotropin stimulating hormones probably by activation mainly of neuropeptide Y receptors located in the somadendritic region of the arcuate DA cell bodies, leading to increased activity in inhibitory tubero-infundibular dopamine neurons
Rettori et al., Gynecol Endocrinol 1990
:
The
role of
neuropeptide Y (NPY) in control of gonadotropin and
prolactin release in the rat ... The results of these studies indicate that
neuropeptide Y plays a very important and often physiologically significant role in the control of LH and
prolactin release by hypothalamic action
Williams et al., Diabetes 1989
(Diabetes Mellitus, Experimental) :
Because both of these regions are important in modulating pituitary hormone secretion, local
NPY increases may be
involved in the impaired secretion of luteinizing hormone, thyroid stimulating hormone, growth hormone, and
prolactin known to occur in STZ-D
Chabot et al., Neuroendocrinology 1988
:
In vitro studies using dispersed anterior pituitary cells indicated that
NPY ( 10 ( -6 ) to 10 ( -9 ) M )
increased the secretion of luteinizing hormone, growth hormone and
prolactin , whereas beta-lipotropin hormone and thyrotropin secretions were not affected
Härfstrand et al., Regul Pept 1987
:
NPY ( 250-750 pmol )
reduced the serum levels of thyreotropine ( TSH ),
prolactin (PRL) and growth hormone (GH) but increased CORTICO, adrenocorticotropin ( ACTH ) and ALDO serum levels ... In conclusion, it is suggested that the NPY induced changes in DA utilization in the tuberoinfundibular DA neurons may contribute to the
NPY induced changes in
PRL and TSH secretion
Garcia de Yebenes et al., Neurosci Lett 1995
:
Involvement of the Y2 receptor subtype in the
regulation of
prolactin gene expression by
neuropeptide Y in the male rat ... In order to determine the influence of neuropeptide Y (NPY) on the biosynthesis of prolactin (PRL), we have studied the
effects of
NPY and some NPY analogs on
PRL gene expression in the male rat anterior pituitary gland
Van Bael et al., J Mol Endocrinol 1994
:
We have studied the
effect of LHRH and
neuropeptide Y (NPY) on
prolactin (PRL) mRNA levels in pituitary reaggregate cell cultures from 14-day-old female rats, by means of in situ hybridization and Northern blot analysis ...
PRL mRNA levels were not
affected by
NPY
Barker-Gibb et al., J Endocrinol 1995
:
NPY18-36 did not produce any significant change in LH pulsatility when injected into the LV, and neither peptide
had any effect on plasma
prolactin or GH levels
Watanobe et al., Neuropeptides 1996
(Pituitary Neoplasms...) :
The GH and
PRL responses to
NPY were considered positive ( a paradoxical increase ) when an increase over baseline of at least 100 % occurred ... Although
NPY did not
affect PRL secretion in any of the patients examined, 60 % ( 9 of 15 ) of the patients showed a significant rise in GH secretion after NPY