Gene interactions and pathways from curated databases and text-mining

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CREB1 — NR4A2

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Zhao et al., Int J Cancer 2011 (Neovascularization, Pathologic) : VEGF stimulates PKD mediated CREB dependent orphan nuclear receptor Nurr1 expression : role in VEGF induced angiogenesis
Ji et al., Br J Pharmacol 2012 : Signalling pathway inhibitors were used to examine the roles of Rho, PKA, the cAMP response element binding protein ( CREB ) and NF-?B on the PGE ( 2 ) stimulated up-regulation of Nurr1
Barneda-Zahonero et al., J Biol Chem 2012 : Our results report a direct regulation of Nurr1 by CREB after NMDAR stimulation
Hawk et al., J Clin Invest 2012 (Memory Disorders) : These CREB regulated Nr4a genes encode ligand independent `` orphan '' nuclear receptors