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EGF — NRG1

Pathways - manually collected, often from reviews:

• Reactome Reaction: EGF → NRG1 (indirect_complex) Cohen et al., J Biol Chem 1996
• Reactome Reaction: EGF → NRG1 (reaction) Vijapurkar et al., Exp Cell Res 2003, Walton et al., J Biol Chem 1990, Li et al., Cell Signal 2007, Xu et al., Mol Cell Biol 2007, Hazan et al., Cell Growth Differ 1990, Kaushansky et al., Chem Biol 2008, Helin et al., J Biol Chem 1991, Margolis et al., J Biol Chem 1989, Ricci et al., Oncogene 1995, Wallasch et al., EMBO J 1995, Prigent et al., EMBO J 1994, Soler et al., Oncogene 1994, Segatto et al., Oncogene 1993, Cohen et al., J Biol Chem 1996, Pinkas-Kramarski et al., EMBO J 1996

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: NRG1 — EGF (in vitro) Karunagaran et al., J Biol Chem 1995*

Text-mined interactions from Literome

Tremblay et al., Gastroenterology 1999 : EGF and/or TGF-alpha down-regulated HGL mRNA levels and decreased enzymic activity
Mao et al., Theriogenology 2012 : The present study determined the effects of supplementation of maturation medium with porcine follicular fluid ( pFF ; 0, 10 %, 20 %, and 30 % ) on mtDNA copy number and oocyte maturation in experiment 1 ; the effects on epidermal growth factor ( EGF ; 10 ng/mL ), neuregulin 1 ( NRG1 ; 20 ng/mL ), and NRG1 + insulin-like growth factor 1 ( IGF1 ; 100 ng/mL + NRG1 20 ng/mL ), on mtDNA copy number, oocyte maturation, and embryo development after parthenogenic activation in experiment 2 ; and effects on embryo development after in vitro fertilization in experiment 3 ... The present study determined the effects of supplementation of maturation medium with porcine follicular fluid ( pFF ; 0, 10 %, 20 %, and 30 % ) on mtDNA copy number and oocyte maturation in experiment 1 ; the effects on epidermal growth factor ( EGF ; 10 ng/mL ), neuregulin 1 ( NRG1 ; 20 ng/mL ), and NRG1 + insulin-like growth factor 1 ( IGF1 ; 100 ng/mL + NRG1 20 ng/mL ), on mtDNA copy number, oocyte maturation, and embryo development after parthenogenic activation in experiment 2 ; and effects on embryo development after in vitro fertilization in experiment 3
Ojeda et al., Mol Cell Endocrinol 1998 : Activation of EGF receptors by TGFalpha, and/or the erbB2/erbB4 receptor complex by NRG , leads to glial release of prostaglandin ( PG ) E2, which then acts directly on LHRH neurons to stimulate LHRH release