◀ Back to INS

INS — NUP43

Text-mined interactions from Literome

Conejo et al., J Cell Physiol 2001 : Insulin ( 50 nM ) rapidly ( 5 min ) stimulated beta-chain insulin receptor, activated the phosphatidylinositol (PI) 3-kinase/Akt/p70S6-kinase signaling pathway, as well as phosphorylated both p44/p42- and p38-mitogen activated protein kinases ( MAPKs )
Gauthier et al., J Cell Biochem 2001 (MAP Kinase Signaling System) : Herein, we report that ( 1 ) the inhibition of signal transduction molecules/pathways revealed striking differences in their impact on cell survival in the jejunum and colon ( e.g., the inhibition of p125Fak induced apoptosis with a significantly greater extent in the jejunum [ approximately 43 % ] than in the colon [ approximately 24 % ] ) ; ( 2 ) sharp distinctions between the two segments were noted in the modulatory effects of the various treatments on Bcl-2 homolog steady-state levels ( e.g., inhibition of tyrosine kinase activities in the jejunum down-regulated all anti-apoptotics analyzed while increasing Bax, whereas the same treatment in the colon down-regulated Bcl-X ( L ) only and increased all pro-apoptotics ) ; and ( 3 ) in addition to their differential impact on cell survival and Bcl-2 homolog expression, the MEK/Erk and P13-K/Akt pathways were found to be distinctively regulated in the jejunum and colon mucosae ( e.g., insulin in the jejunum increased p42Erk-2 activation without affecting that of p57Akt, whereas the same treatment in the colon decreased p42Erk-2 activation while increasing that of p57Akt )
Massao Hirabara et al., FEBS Lett 2003 : Palmitate reduced insulin stimulated phosphorylation of insulin receptor substrate-1/2, Akt, and p44/42 mitogen activated protein kinases
Kralisch et al., Mol Cell Endocrinol 2005 : Moreover, p44/42 mitogen activated protein kinase appears to partly mediate the negative effect of insulin but not TNFalpha on ATGL
Stricker et al., J Neurochem 2006 : Interaction of the brain-specific protein p42IP4/centaurin-alpha1 with the peptidase nardilysin is regulated by the cognate ligands of p42IP4, PtdIns ( 3,4,5 ) P3 and Ins ( 1,3,4,5 ) P4, with stereospecificity
Harwood et al., J Biol Chem 2008 (MAP Kinase Signaling System) : The effect of rapamycin on IGF-I or insulin activation of p44/42 was recapitulated by amino acid deprivation
Hunter et al., Ciba Found Symp 1985 (Cell Transformation, Viral) : IGF I and insulin , whose receptors also have ligand stimulated protein-tyrosine kinase activity, induce p42 phosphorylation in appropriate cells
Sharma et al., Mol Cell Biol 1997 : In both cell types, overexpression of either the PTB or the SAIN protein caused a significant decrease in insulin induced tyrosine phosphorylation of IRS-1 and Shc proteins, IRS-1 associated phosphatidylinositol 3-kinase (PI 3-K) enzymatic activity, p70s6k activation, and p44 and p42 mitogen activated protein kinase ( MAPK ) phosphorylation
Porras et al., Mol Endocrinol 1998 : These results indicate that MEK mediates the IGF-I/insulin induced p42/ p44 MAPK activation