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ODC1 — PRL
Text-mined interactions from Literome
Hsu et al., Apoptosis 2006
:
Prolactin induced
ODC activity is completely blocked by a protein kinase C delta (PKCdelta) inhibitor, rottlerin ... It indicates that
prolactin may
induce ODC activity through the PCKdelta pathway
Ibrahim et al., J Exp Zool 1991
:
We previously reported that
prolactin (PRL) could
increase the activity of
ornithine decarboxylase (ODC) in liver slices taken from larval tiger salamanders ( Ambystoma tigrinum ) ... The same set of treatments which we have shown to modify
PRL effects on
ODC in liver slices affects PRL action in the tail skin in a parallel manner ... Thus, the mechanism whereby
PRL enhances
ODC activity appears to be the same in both these tissues
Buckley et al., Life Sci 1991
:
Prolactin also significantly
enhanced radiolabel incorporation into triacylglycerol and phospholipids within 10 minutes and induced
ODC activity at 6 hours
Gonzalez et al., Biol Reprod 1991
(Dwarfism...) :
Furthermore,
ornithine decarboxylase (ODC) is considered a key enzyme in the biosynthesis of polyamines and is
regulated by
PRL in certain target tissues
Russell et al., Immunopharmacology 1985
:
Marked inhibition of
prolactin stimulated
ODC activity occurred at 0.12 mg CsA/kg body weight, and nearly total inhibition was detected at 1.2 mg CsA/kg, a dose comparable to that used to suppress organ rejection processes
Rillema et al., Proc Soc Exp Biol Med 1985
:
These observations are compatible with the thesis that the
stimulation of
ODC activity by
PRL may occur via an activation of protein kinase C
Rui et al., Mol Cell Endocrinol 1987
:
In androgenized hypophysectomized rats, ovine
prolactin stimulated the activity of the
ornithine decarboxylase (ODC) of the lateral lobes, but not the ventral and dorsal lobes of the prostate glands in a time- and dose dependent fashion
Jones et al., Toxicol Appl Pharmacol 1987
:
In addition, the effects of TCDD on PRL receptor activity, as assessed by the ability of
PRL to
induce ornithine decarboxylase (ODC) , were determined ... By 7 days, liver
ODC activity in
response to
PRL was only 12 % that detected in pair fed controls
Russell et al., Mol Cell Endocrinol 1984
:
The marked effect of CyA to selectively block
ODC induction by
PRL may be due to the ability of CyA to interact with receptor required phospholipids in membranes and thus to antagonize hormone-receptor interaction
Rillema et al., Horm Metab Res 1982
:
IBMX by itself, stimulated ornithine decarboxylase (ODC) activity in a dose-response fashion ; but the IBMX at concentrations up to 1 mM had no effect on the magnitude of the
prolactin stimulated
ODC activity
Wing et al., Prostaglandins 1983
:
The
prolactin action on
ODC activity was attenuated by indomethacin, an inhibitor of prostaglandin biosynthesis
Rillema et al., Proc Soc Exp Biol Med 1983
:
alpha-Difluoro methyl ornithine ( DFMO ), an irreversible inhibitor of ornithine decarboxylase activity, reduces the
PRL stimulated
ornithine decarboxylase (ODC) activity by more than 95 %, and yet does not suppress the effects of PRL on RNA, casein or lipid synthesis ... These observations suggest that
PRL 's early
action on
ODC activity is not essential for the subsequent actions of PRL on the synthesis of certain of the components of milk
Rillema et al., Endocrinology 1983
:
These results suggest that
PRL , PLA2, and PLC
stimulate ODC activity via similar mechanisms in the mammary gland and make tenable the idea that the action of PRL on ODC activity may be carried out via an action of PRL on PL activity
Nishiguchi et al., Leuk Res 1993
(Leukemia, Promyelocytic, Acute) :
These
effects of
PRL on cellular proliferation,
ODC activity and DNA synthesis were abolished by the simultaneous addition of anti-hPRL antibody
Wang et al., J Neurosci 1996
:
Prolactin (PRL) injected subcutaneously
increased hepatic
ODC activity as well as mRNA levels of ODC and the proto-oncogenes c-fos, c-jun, junB, junD, c-myc, and max ... MS significantly suppressed
PRL induced increases in
ODC enzyme activity and c-myc, max, and ODC mRNAs but had little effect on expression of the other proto-oncogenes ...
PRL induced stimulation of
ODC , c-myc, and max mRNAs also was depressed in neonates placed with an anesthetized lactating dam ( touch deprived ) but not in pups placed with nipple ligated dams ( food deprived )
Neidhart et al., Experientia 1996
:
A
role for
Prl in the induction of
ODC in liver and lymphoid tissues is suggested by the fact that CBLA suppresses this enhancement