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P2RX7 — PLD6

Text-mined interactions from Literome

Sun et al., J Neurochem 1999 : Taken together, these data indicate that activation of the P2X7 receptors induces Ca2+ influx and stimulates a Ca2+ dependent PLD in RBA-2 astrocytes
Hung et al., Cell Signal 2002 : GF 109203X, a selective protein kinase C ( PKC ) inhibitor, partially inhibited the P2X(7)R mediated PLD activation, while blocking the phorbol 12-myristate 13-acetate ( PMA ) -stimulated PLD activity ... In addition, PMA synergistically activated the P2X(7)R mediated PLD activity ... No additive inhibitory effects were found by simultaneous treatment of GF 109203X and KN62 on P2X(7)R activated PLD ... Taken together, these results demonstrate that both PKC dependent and PKC independent signaling pathways are involved in the regulation of P2X(7)R mediated PLD activation ... Additionally, CaMKII may participate in the PKC dependent pathway, and tyrosine kinase may play a pivotal role on both PKC dependent and PKC independent pathways in the P2X(7)R mediated PLD activation in RBA-2 cells
Divald et al., Placenta 2002 : These results and the dependence of PLD on PKC activity implies that a restricted, membrane localized calcium flux activates PKC and in turn, mediates the P(2X7) dependent stimulation of PLD
Pochet et al., Cell Signal 2003 (Calcium Signaling) : Regulation of phospholipase D by P2X7 receptors in submandibular ductal cells
Coutinho-Silva et al., Immunity 2003 (Chlamydia Infections) : Inhibition of chlamydial infectious activity due to P2X7R dependent phospholipase D activation ... These results suggest that P2X(7)R ligation leads to PLD activation, which is directly responsible for inhibition of infection
Shemon et al., Immunol Cell Biol 2007 (Leukemia, Lymphocytic, Chronic, B-Cell) : The inhibition of P2X(7) stimulated PLD activity by rottlerin was attributed to a target downstream of P2X(7) activation, as the ATP mediated ( 86 ) Rb ( + ) efflux from CLL B-lymphocytes was not altered in the presence of rottlerin ... Our results indicate a possible role for novel PKC isoforms in the regulation of P2X(7) mediated PLD activity
Le Stunff et al., Cell Signal 2007 (Ion Channel Gating) : Here we present evidence that early P2X7R mediated PLD activation reduces pore opening and delays cytolysis of RAW 267.4 macrophages induced by ATPe
el-Moatassim et al., J Biol Chem 1993 : Thus, choline, which enters the cells through the BzATP induced pores, can act to inhibit P2z receptor stimulated PLD activity but not pore formation