Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Han et al., Cell Signal 2008 (Tuberous Sclerosis) : Pam ( Protein associated with Myc ) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling ... Our results provide novel evidence that Pam can function as an E3 Ub ligase toward tuberin and regulate mTOR signaling , suggesting that Pam can in turn regulate cell growth and proliferation as well as neuronal function through the TSC/mTOR pathway in mammalian cells
Maeurer et al., Cell Signal 2009 : Sphingosine-1-phosphate induced mTOR-activation is mediated by the E3-ubiquitin ligase PAM
Han et al., J Biol Chem 2012 : Our results establish that Pam regulates TSC/mTOR signaling in vitro and in vivo through two distinct domains
Bahl et al., Molecular autism 2013 : Pam , an E3 ubiquitin ligase, binds to TSC proteins and regulates mTORC1 signaling in the CNS, and the FBXO45-Pam ubiquitin ligase complex plays an essential role in neurodevelopment by regulating synapse formation and growth