Gene interactions and pathways from curated databases and text-mining

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IL4 — PIK3R1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Ceponis et al., J Biol Chem 2000 : In contrast, although the PI3K inhibitors wortmannin and LY294002 did not affect IL-4 or IL-13 STAT 6 activation, they significantly inhibited the ability of either cytokine to lower TER
Frossi et al., J Immunol 2007 : Selective activation of Fyn/PI3K and p38 MAPK regulates IL-4 production in BMMC under nontoxic stress condition
O'Connor et al., J Immunol 2007 (Diabetes Mellitus, Type 2) : Examination of IL-4 signaling in db/db macrophages revealed that IL-4 dependent IRS-2/PI3K complex formation and IRS-2 tyrosine phosphorylation was reduced compared with db/+ macrophages ... These results indicate that in the db/db mouse model of T2D, macrophage expression of SOCS-3 is increased, and impaired IL-4 dependent IRS-2/PI3K formation induces a state of IL-4 resistance that disrupts IL-4 dependent production of IL-1RA
Venkatachalam et al., Am J Physiol Heart Circ Physiol 2008 (Hyperglycemia) : Resveratrol inhibits high glucose induced PI3K/Akt/ERK dependent interleukin-17 expression in primary mouse cardiac fibroblasts
Xia et al., Mol Cell Biochem 2012 (Asthma...) : We investigated the effects of PI3K inhibitor wortmannin on iNOS expression in bronchiole epithelial cells and NO, IL-4 and IFN-? levels in lung tissues of asthmatic rat model, which was prepared by 10 % OVA solution sensitization and 1 % OVA aerosol challenge
Bavelloni et al., J Cell Sci 1999 (Osteosarcoma) : Phosphatidylinositol 3-kinase translocation to the nucleus is induced by interleukin 1 and prevented by mutation of interleukin 1 receptor in human osteosarcoma Saos-2 cells