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APP — PLA2G1B

Text-mined interactions from Literome

Gattaz et al., J Neural Transm 2004 (Alzheimer Disease) : In the brain the inhibition of PLA(2) inhibits the physiological secretion of the APP , a mechanism that increases Abeta formation
Ghiara et al., Biochem Pharmacol 1984 : APP I revealed a mol. wt of 200 k with a small fragment of 15 k and inhibited membrane bound PLA2 ; APP II revealed a mol. wt of 40 k and inhibited lysosomal PLA2
Gattaz et al., Fortschr Neurol Psychiatr 1996 (Alzheimer Disease) : Decreased PLA2 activity may inhibit the secretion of the amyloid precursor protein (APP) and thus contribute to the formation of the beta-amyloid peptide, the major component of the amyloid plaque in AD