Gene interactions and pathways from curated databases and text-mining

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IFNG — PLA2G4A

Text-mined interactions from Literome

Hayashi et al., Cytokine 2000 : These results indicate that IL-1beta induced delayed PGE ( 2 ) generation in these human fibroblasts mainly depends on de novo induction of COX-2 and cPLA(2) , irrespective of the constitutive presence of COX-1, and that IFN-gamma and IL-4 inhibit IL-1beta induced delayed PGE ( 2 ) generation by suppressing, predominantly, COX-2 expression
Gomez-MarĂ­n et al., Parasitol Res 2002 : Thus, IFN gamma blocks the activities of both THP1 and parasite sPLA2 and cPLA2 in membrane fractions, resulting in protection against active invasion by T. gondii
Wu et al., J Clin Invest 1994 : We report that IFN-gamma induces the synthesis and prolonged activation of cytosolic phospholipase A2 (cPLA2) in a human bronchial epithelial cell line ( BEAS 2B ) ... Subcellular enzyme activity assay revealed that IFN-gamma increased PLA2 activity in both the cytosol and membrane fractions with a translocation of the cPLA2 to cell membranes in a Ca ( 2+ ) -free cell lysing buffer ... Nuclear run-on assay demonstrated that IFN-gamma initiated cPLA2 gene transcription within 15 min, and this effect was sustained at 4 h and returned to near control level at 12 h ... Furthermore, the IFN-gamma induced cPLA2 mRNA increase was blocked by inhibitors of protein kinase C and calcium/calmodulin dependent protein kinases, suggesting the involvement of these protein kinases in IFN-gamma induced gene expression of cPLA2 ... This study shows that IFN-gamma induces the synthesis and prolonged activation of cPLA2