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IFNG — PLA2G4A
Text-mined interactions from Literome
Hayashi et al., Cytokine 2000
:
These results indicate that IL-1beta induced delayed PGE ( 2 ) generation in these human fibroblasts mainly depends on de novo induction of COX-2 and
cPLA(2) , irrespective of the constitutive presence of COX-1, and that
IFN-gamma and IL-4
inhibit IL-1beta induced delayed PGE ( 2 ) generation by suppressing, predominantly, COX-2 expression
Gomez-MarĂn et al., Parasitol Res 2002
:
Thus,
IFN gamma blocks the activities of both THP1 and parasite sPLA2 and
cPLA2 in membrane fractions, resulting in protection against active invasion by T. gondii
Wu et al., J Clin Invest 1994
:
We report that
IFN-gamma induces the synthesis and prolonged activation of
cytosolic phospholipase A2 (cPLA2) in a human bronchial epithelial cell line ( BEAS 2B ) ... Subcellular enzyme activity assay revealed that
IFN-gamma increased PLA2 activity in both the cytosol and membrane fractions with a translocation of the
cPLA2 to cell membranes in a Ca ( 2+ ) -free cell lysing buffer ... Nuclear run-on assay demonstrated that
IFN-gamma initiated
cPLA2 gene transcription within 15 min, and this effect was sustained at 4 h and returned to near control level at 12 h ... Furthermore, the IFN-gamma induced cPLA2 mRNA increase was blocked by inhibitors of protein kinase C and calcium/calmodulin dependent protein kinases, suggesting the involvement of these protein kinases in
IFN-gamma induced gene expression of
cPLA2 ... This study shows that
IFN-gamma induces the synthesis and prolonged activation of
cPLA2