Gene interactions and pathways from curated databases and text-mining

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PLD5 — RAC1

Text-mined interactions from Literome

Santy et al., J Cell Biol 2001 : However, inhibition of PLD does not prevent activation of Rac
Hess et al., J Biol Chem 1997 : In contrast, in cells treated with platelet derived growth factor ( PDGF ) or phorbol ester, the wtRac1 cells showed little or no enhancement of PLD activity, and the response was not affected in the N17Rac1 cells, implying that Rac1 played a minimal role in the activation of PLD by PDGF or protein kinase C ... In summary, these data indicate a major role for Rac1 in the activation of PLD by EGF, but not PDGF or protein kinase C