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PLD5 — RPTOR

Text-mined interactions from Literome

Kam et al., FASEB J 2004 : The reduction in PLD activity in both situations impaired the effect of LPA on mTOR signaling but did not inhibit the effect of PDGF
Hornberger et al., Proc Natl Acad Sci U S A 2006 : The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle ... Finally, pharmacological inhibition of PLD blocked the mechanically induced increase in PA and the activation of mTOR signaling
Yoon et al., J Cell Sci 2008 : Instead, PLD1 positively regulates mTOR signaling leading to the production of IGF2, an autocrine factor instrumental for the initiation of satellite cell differentiation
Suryawan et al., J Appl Physiol 2010 : Our results suggest that the enhanced activation of mTORC1 in muscle of neonatal pigs is in part due to regulation by PRAS40, PLD1 , and the Rag GTPases
Arous et al., Diabetologia 2011 : Oleate mediated mTORC1 activation required phospholipase D activation, which produces phosphatidic acid and is known to render mTORC1 rapamycin resistant
Razmara et al., Cell communication and signaling : CCS 2013 : In addition, PDGF-BB induced activation of mTORC1 , as measured by phosphorylation of the downstream S6 protein, was dependent on phospholipase D ( PLD ) ... mTORC1 is activated in a PLD dependent manner and promotes phosphorylation of the S6 protein, whereas mTORC2, in concert with PLC? signaling, promotes Akt phosphorylation
Jaafar et al., Cell communication and signaling : CCS 2013 (Muscular Atrophy) : It is established that Phospholipase D ( PLD ) activates mTOR signaling , through the binding of its product phosphatidic acid ( PA ) to mTOR protein