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Text-mined interactions from Literome
Hensley et al., Neurosci Lett 2000
:
CPI-1189 inhibits
interleukin 1beta induced
p38-mitogen activated protein kinase phosphorylation : an explanation for its neuroprotective properties ?
Pavlovic et al., Eur Cytokine Netw 2000
(Diabetes Mellitus, Type 1) :
It has been reported recently that
interleukin-1 beta (IL-1 beta) induces activation of the mitogen activated protein kinases ( MAPK )
p38 and ERK1/2 in neonatal rat islets ... We conclude that
IL-1 beta induces activation of both
p38 and ERK1/2, and that ERK1/2 contributes to the pro-apoptotic effects of the cytokine in primary beta-cells
Sprinkel et al., Eur Cytokine Netw 2001
:
Glucose potentiates
interleukin-1 beta (IL-1 beta) induced
p38 mitogen activated protein kinase activity in rat pancreatic islets of Langerhans
Moore et al., J Appl Physiol 2001
:
Although
IL-1 beta and TNF-alpha each
increased nuclear factor-kappa B activation and induced extracellular regulated kinase and
p38 phosphorylation, combined administration of the cytokines did not enhance either nuclear factor-kappa B or mitogen activated protein kinase activation
Masamune et al., Pancreas 2002
(Acute Disease...) :
IL-1 beta and TNF-alpha
activated extracellular signal regulated kinase 1/2, c-Jun N-terminal kinase/stress activated protein kinase, and
p38 mitogen activated protein kinase
Kabouridis et al., J Immunol 2002
(MAP Kinase Signaling System) :
In contrast, exogenously added TAT-srIkappaBalpha did not inhibit
IL-1beta induced activation of extracellular signal regulated kinase, c-Jun N-terminal kinase, or
p38 mitogen activated protein kinases or the phosphorylation and degradation of endogenous IkappaBalpha
Degousee et al., Circ Res 2003
(MAP Kinase Signaling System) :
Interleukin-1beta induced the phosphorylation of
p38alpha and p38beta2 MAPK in cardiomyocytes and stimulated RNA polymerase II binding to the COX-2 promoter, COX-2 transcription, COX-2 protein synthesis, and prostaglandin E2 ( PGE2 ) release
Lin et al., J Biomed Sci 2004
:
This hypothesis was further supported by the transient activation of p42/p44 and
p38 MAPKs
induced by
IL-1beta
Migita et al., Rheumatology (Oxford) 2005
:
A77 1726 inhibited
IL-1beta induced
p38 and c-Jun N-terminal kinase 1/2 ( JNK1/2 ) activation, whereas A77 1726 did not affect IL-1beta induced NF-kappaB activation in hepatocytes
Sung et al., J Neurochem 2005
(Hyperalgesia) :
However, pretreatment with a p38 MAPK inhibitor significantly reduced the
IL-1beta induced
p-p38 MAPK expression by 38-49 %, and nearly completely blocked the subsequent iNOS expression ( reduction by 86.6 % ), NO production, and thermal hyperalgesia
Nieminen et al., Mediators Inflamm 2005
:
Proinflammatory cytokine
IL-1beta caused a transient activation of Erk1/2,
p38 , and JNK in immortalized human T/C28a2 chondrocytes and that was followed by enhanced COX-2 expression and PGE2 production
Jia et al., Zhonghua Wai Ke Za Zhi 2005
(Disease Models, Animal...) :
Similarly, the increased gene expression of proinflammatory cytokines TNF-alpha and
IL-1beta in gastric mucosa induced by WIR stress were significantly
diminished by
p38 MAPK inhibition
Lee et al., World J Gastroenterol 2006
(MAP Kinase Signaling System) :
IL-1beta activates p44/42 and
p38 mitogen activated protein kinases via different pathways in cat esophageal smooth muscle cells
Kesherwani et al., Cytokine 2007
:
Quantitative
role of p42/44 and
p38 in the production and regulation of cytokines TNF-alpha,
IL-1beta and IL-12 by murine peritoneal macrophages in vitro by concanavalin A ... In the present study the quantitative
role of p42/44 and
p38 in the production of TNF-alpha,
IL-1beta and IL-12 by murine peritoneal macrophages, in vitro, on treatment with Concanavalin A ( ConA ) has been investigated
Ho et al., Biochem Pharmacol 2007
:
In contrast, IL-1beta mediated ERK and JNK activations were not changed by LCY-2-CHO, while
p38 activation by
IL-1beta and LCY-2-CHO displayed the non-additivity
Li et al., Shock 2007
:
CCK-8
inhibits LPS induced
IL-1beta production in pulmonary interstitial macrophages by modulating PKA,
p38 , and NF-kappaB pathway
Kwon et al., Life Sci 2007
:
IL-1 beta release and caspase-1 activity induced by DSS were significantly
inhibited by a MAPK kinase 1/2 inhibitor, a
p38 MAPK inhibitor, and NAC, however, not by JNK1/2 or a protein kinase C inhibitor
Wang et al., Endocrinology 2007
:
In addition, our results showed that IFN-gamma/IL-1beta enhance p38 MAPK phosphorylation and that SB 203580, a p38 MAPK inhibitor, can inhibit
IFN-gamma/IL-1beta induced
p38 MAPK phosphorylation
Lu et al., Mol Immunol 2008
:
Moreover, the rIL-1beta induced
IL-1beta and COX-2 expression were
reduced by
p38 MAPK inhibitor ( SB203580 ) and JNK inhibitor ( SP600125 ), respectively
Busik et al., Diabetes 2008
(Diabetic Retinopathy...) :
Exposure of HRECs to 25 mmol/l glucose did not stimulate endogenous ROS production,
activation of nuclear factor-kappaB (NF-kappaB), extracellular signal related kinase ( ERK ),
p38 and Jun NH ( 2 ) -terminal kinase ( JNK ), tyrosine phosphorylation, interleukin
(IL)-1beta , or tumor necrosis factor-alpha (TNF-alpha) production and only slightly affected apoptotic cell death pathways compared with normal glucose ( 5 mmol/l )
Brechter et al., Bone 2008
:
Phospho-ELISA and Western blots showed that
IL-1beta activated JNK and
p38 , but not ERK 1/2 MAP kinase
Illek et al., Am J Physiol Lung Cell Mol Physiol 2008
:
Neither flagellin nor
IL-1beta altered transepithelial fluxes of membrane-impermeant dextran ( 10 kDa ) or lucifer yellow ( mol wt = 457 ), but both
activated p38 , NF-kappaB, and IL-8 secretion
Noh et al., Rheumatology (Oxford) 2009
(Arthritis, Rheumatoid...) :
Moreover, cordycepin significantly inhibited
IL-1beta induced
p38/JNK and AP-1 activation, but not extracellular signal regulated kinase ( ERK ) and NF-kappaB activation
Sheng et al., J Neuroimmune Pharmacol 2009
(MAP Kinase Signaling System) :
IL-1beta triggered the activation of p38 and ERK1/2 ( p44/42) MAP kinase (MAPK) signaling pathways, but WIN55,212-2 mainly
inhibited p38 MAPK phosphorylation
Hastings et al., Arterioscler Thromb Vasc Biol 2009
(Atherosclerosis) :
Neutralization of the IL-8 receptor, CXCR2, further induced VCAM-1 in the
presence of
IL-1beta , and
phospho-p38 was required for NF-kappaB activation and VCAM-1 expression ... Additionally, IL-8 reduced
p38 activation and NF-kappaB activity
induced by
IL-1beta alone