Gene interactions and pathways from curated databases and text-mining

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NOS2 — PPP3R1

Text-mined interactions from Literome

Obasanjo-Blackshire et al., Cardiovasc Res 2006 (Myocardial Ischemia) : Calcineurin regulates NFAT dependent iNOS expression and protection of cardiomyocytes : co-operation with Src tyrosine kinase
Hämäläinen et al., Int Immunopharmacol 2009 : Calcineurin inhibitors ( CsA, FK-506 and pimecrolimus ) inhibited NO production and iNOS expression in a concentration dependent manner, CsA being more potent than FK-506 and pimecrolimus
Foster et al., American journal of physiology. Renal physiology 2009 (Diabetes Mellitus, Experimental...) : In conclusion, while NO bioavailability in mTALs is reduced during diabetes, free radical scavenging with tempol unmasks increased NO production that involves PP2B dependent activation of NOS1 and NOS2