Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Lochhead et al., Diabetes 2000 : Several lines of evidence suggest that the insulin-mimetic effects of AICAR are mediated by activation of AMPK ... Also, insulin does not activate AMPK in H4IIE cells, suggesting that this protein kinase does not link the insulin receptor to the PEPCK and G6Pase gene promoters
Hayashi et al., Diabetes 2000 : Insulin stimulated glucose transport by 6.5-fold above basal but did not affect AMPK activity
Winder et al., J Appl Physiol 2000 : Insulin attenuated the increase in AMPK caused by AICAR both in perfused hindlimbs and in isolated epitrochlearis muscles
Barnes et al., Diabetes 2002 (Anoxia...) : We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK , and glucose transport activity in epitrochlearis skeletal muscle from insulin-resistant Zucker ( fa/ fa ) rats ... Isoform-specific AMPK activity was measured in skeletal muscle in response to insulin , contraction, or hypoxia
Ruderman et al., Biochem Soc Trans 2003 (Diabetes Mellitus...) : ( iii ) Activation of AMP activated protein kinase (AMPK) inhibits all of these events and enhances insulin signalling in the endothelial cell
da Silva Xavier et al., Biochem J 2003 : Thus forced increases in AMPK activity achieved pharmacologically with 5-amino-4-imidazolecarboxamide riboside ( AICAR ), or by adenoviral overexpression of a truncated, constitutively active form of the enzyme ( AMPK alpha 1.T ( 172 ) D ), blocked glucose stimulated insulin secretion ... These results indicate that inhibition of AMPK by glucose is essential for the activation of insulin secretion by the sugar, and may contribute to the transcriptional stimulation of the preproinsulin gene
Kovacic et al., J Biol Chem 2003 : In addition, insulin caused an increase in Akt phosphorylation and a decrease in AMPK phosphorylation at its major regulatory site ( threonine 172 of the alpha catalytic subunit ) ... In addition, our data suggest that the ability of insulin to inhibit AMPK may be controlled via an Akt mediated mechanism
Witters et al., J Biol Chem 1992 (Liver Neoplasms, Experimental) : In the present study, we have examined, in Fao hepatoma cells, the effects of insulin on ACC and AMPK activity, the latter measured with a synthetic peptide corresponding to one of the phosphorylation sites on ACC for AMPK
Fleming et al., Thromb Haemost 2003 : In platelets, but not in endothelial cells, insulin induced the activation of the AMP activated protein kinase (AMPK) , a metabolic stress sensing kinase which was sensitive to the phosphatidylinositol 3-kinase (PI3-K) inhibitor wortmannin and the AMPK inhibitor iodotubercidin
Carling et al., Biochimie 2005 : In the hypothalamus, AMPK is inhibited by leptin and insulin , hormones which suppress feeding, whilst ghrelin, a hormone that increases food intake, activates AMPK
Roman et al., J Physiol 2005 (Anorexia...) : Finally, cold exposure significantly impaired insulin induced inhibition of AMPK through a mechanism dependent on the molecular cross-talk between phosphatidylinositol-3(PI3)-kinase/Akt and AMPK
Longnus et al., Diabetologia 2005 : In order to characterise interactions between the insulin- and AMPK signalling pathways, we investigated the effects of AMPK activation on insulin signalling in the rat heart in vivo ... In addition, we found that AMPK inhibits insulin stimulation of IRS1 associated phosphatidylinositol 3-kinase activity, and that AMPK activates atypical protein kinase C and extracellular signal regulated kinase in the heart
Folmes et al., Circ Res 2006 (Myocardial Ischemia) : In the presence of 0.2 or 1.2 mmol x L ( -1 ) palmitate, insulin stimulated glycolysis by 111 % and 105 % and glucose oxidation by 72 % and 274 % but no longer inhibited AMPK activity ... We demonstrate that the cardioprotective effect of insulin and its ability to inhibit AMPK activity are lost in the presence of high concentrations of fatty acids
Gleason et al., J Biol Chem 2007 : Moreover, activation of AMPK by AICAR or phenformin did not antagonize glucose stimulated insulin secretion, and insulin secretion was also unaffected in response to suppression of AMPK activity by expression of a dominant negative AMPK construct ( K45R )
Wang et al., Life Sci 2007 : Changes in AMP activated protein kinase (AMPK) activity contribute to the regulation of insulin secretion ... One-hour troglitazone treatment activated AMPK and inhibited both glucose stimulated insulin secretion ( GSIS ) and the response of insulin secretion to combined stimuli of glucose and palmitate
Kim et al., Biochem Biophys Res Commun 2008 : It is well known that the activation of AMP activated protein kinase (AMPK) represses insulin gene expression and glucose stimulated insulin secretion ... We investigate whether BETA2 gene expression are involved in the AMPK mediated regulation of insulin gene expression in normal and dysfunctional beta-cells ... These results demonstrate that the expressions of BETA2 and insulin gene are positively regulated by glucose and negatively by AMPK
Deshmukh et al., Mol Endocrinol 2008 : AMPK activation reduces muscle protein synthesis by down regulating mTOR signaling, whereas insulin mediates mTOR signaling via Akt activation
Cesquini et al., Life Sci 2008 (Body Weight) : The pharmacological blockade of beta3-adrenergic receptor ( SR 59230A ) blocked the effect of ICV citrate and citrate plus insulin on liver AMPK phosphorylation
Louden et al., Reproduction 2008 (Insulin Resistance) : Surprisingly, disrupted insulin signaling led to decreased AMPK activity in TS cells ... Decreased insulin signaling also resulted in decreased AMPK activation
Omar et al., Cell Signal 2009 : The diminishing effect of insulin on AMPK activation was reversed upon treatment with the PDE3B specific inhibitor OPC3911 but not with the PDE4 inhibitor Rolipram
Funai et al., Diabetes 2009 : To evaluate the roles of AMPK and Akt on insulin- or contraction stimulated PAS-AS160, PAS-TBC1D1, and glucose transport, rat epitrochlearis was incubated with and without compound C ( inhibitor of AMPK ) or Wortmannin ( inhibitor of phosphatidylinositol [ PI] 3-kinase, which is upstream of Akt ) before and during insulin stimulation or contraction
Zhu et al., Placenta 2009 (Obesity) : The objective of this study was to assess the activity of AMPK and its role in the observed down-regulation of insulin/IGF-1 signaling in cotyledonary (COT) arteries supplying the placental component of the ewe placentome
Gruzman et al., Rev Diabet Stud 2009 : We have recently discovered a new class of hydrophobic D-xylose derivatives that activates AMPK in skeletal muscles in a non insulin dependent manner
Chotechuang et al., Am J Physiol Endocrinol Metab 2009 : The present findings demonstrate that AAs and insulin exert a coordinated action on translation and involved mTOR, AMPK , and GCN2 transduction pathways
Okazaki et al., Endocr J 2010 : In conclusion, suppression of AMPK activity in beta-cells inhibited insulin secretion in response to glucose, potassium chloride or glibenclamide without altering insulin content
Hoehn et al., Cell Metab 2010 : Hence, AMPK and ACC have become major drug targets for weight loss and improved insulin action
Tao et al., Journal of molecular signaling 2010 : AMPK activation improves insulin sensitivity via multiple mechanisms, among which AMPK suppresses mTOR/S6K mediated negative feedback regulation of insulin signaling ... In the present study we further investigated the mechanism of AMPK regulated insulin signaling
Sun et al., Am J Physiol Endocrinol Metab 2010 (Body Weight...) : We conclude that LKB1 and AMPK play distinct roles in the control of insulin secretion and that the timing of LKB1 deletion, and/or its loss from extrapancreatic sites, influences the final impact on beta-cell function
Gaidhu et al., Mol Endocrinol 2010 : Subsequently, basal and insulin stimulated glucose uptake and the phosphorylation of AMPK , acetyl-CoA carboxylase, Akt, and the Akt substrate of 160 kDa ( AS160/TBC1D4 ) were determined
Liu et al., Cell Signal 2010 : Using specific inhibitors to key kinases of both pathways and PKCzeta small interference RNA, protein kinase C zeta (PKCzeta) was found to regulate insulin stimulated protein kinase B (PKB) activation and inhibit AMPK activity on dorsal cell surface
Liu et al., FASEB J 2010 : These studies demonstrate that a change in cellular energy state is associated with AMPK activation by both adiponectin and insulin , which requires the activity of FATP1 and Acsl1
Garcia-Haro et al., FASEB J 2010 : R6 interacts physically with the ß-subunit of the AMPK complex and recruits PP1 to dephosphorylate the catalytic a-subunit on Thr172. siRNA depletion of R6 decreases glucose induced insulin secretion due to the presence of a constitutively active AMPK complex
Becker et al., Diabetes 2010 (Body Weight...) : Chemerin reduced insulin stimulated Akt1 phosphorylation and activation of 5'AMP activated protein kinase (AMPK) in the skeletal muscle, but had no effect on Akt phosphorylation and insulin stimulated AMPK activation in the liver and gonadal adipose tissue
Moreno-Navarrete et al., J Nutr Biochem 2011 (Inflammation) : In conclusion, these results suggest that lactoferrin promotes adipogenesis in human adipocytes by enhancing insulin signaling and inhibiting RB1 and AMPK activities
Shah et al., Arch Biochem Biophys 2011 : Compound C, a specific AMPK inhibitor, completely blocked the potentiating effects of AICAR on insulin signaling and glucose uptake, thus suggesting that AMPK mediates effects of AICAR on insulin signaling
Gorres et al., J Physiol 2011 : On the fourth day, insulin stimulated skeletal muscle glucose uptake was measured in vitro and insulin signalling intermediates were assessed via Western blotting.Activation of ERa with PPT resulted in increased insulin stimulated glucose uptake into the slow-twitch soleus and fast-twitch extensor digitorum longus ( EDL ) muscles, activation of insulin signalling intermediates ( as measured by phospho-Akt ( pAkt ) and pAkt substrate ( PAS ) ) and phosphorylation of AMP activated protein kinase (AMPK)
Ginion et al., Am J Physiol Heart Circ Physiol 2011 (Insulin Resistance) : Mimicking AMPK activators in the presence of insulin , rapamycin inhibited p70S6K and reduced IRS-1 phosphorylation on serine, resulting in the overphosphorylation of PKB/Akt and AS160
Aljada et al., Pharmacol Ther 2012 (Neoplasms) : This action may be mediated through activation of AMP activated protein kinase (AMPK) , inhibition of the mammalian target of rapamycin (mTOR) pathway, and inhibition of insulin like growth factors (IGFs) , and many others
Cui et al., Cardiovasc Res 2012 (MAP Kinase Signaling System) : Akt and extracellular signal regulated kinase 1/2 ( ERK1/2 ) phosphorylation was increased in insulin treated hearts and in NRVMs. P13K inhibitor LY294002 and Akt1/2 kinase inhibitor but not the ERK1/2 kinase ( MEK ) inhibitors PD98059 and U0126 blocked the insulin induced reduction in AdipoR1 expression and AMPK phosphorylation
Langelueddecke et al., Cell Physiol Biochem 2012 (Insulinoma) : In addition to K ( ATP ) channels, the AMP dependent protein kinase (AMPK) , a major cellular fuel sensor in a variety of cells and tissues, also affects insulin secretion and ß-cell survival ... We therefore tested the effects of AMPK activators ( AICAR and metformin ), and compound C on AMPK phosphorylation, insulin secretion, K ( ATP ) channel currents, cell membrane potential, intracellular calcium concentration, apoptosis and cell cycle distribution of INS-1E cells under standard cell culture conditions ( 11 mM glucose )
Sonntag et al., FEBS J 2012 : Surprisingly, we observed that AMPK not only responds to energy deprivation but can also be activated by insulin , and is further induced in mTORC1-deficient cells
de Castro Barbosa et al., Metabolism 2013 : L-NAME treatment suppressed Arg effects on : 1 ) nitrite and c-GMP content ; 2 ) glycogen synthesis and glucose uptake ; 3 ) basal and insulin stimulated p-Akt ( Ser ( 473 ) ), total and p-AMPK-a and ACC, and nNOS expression
Hebbachi et al., Biosci Rep 2013 : While insulin had no effect on basal AMPK activity insulin did decrease AMPK activity in the presence of palmitate and also decreased the percentage effectiveness of palmitate to increase the transport of 2-DOG
Steinbusch et al., J Mol Cell Cardiol 2013 (Insulin Resistance) : Overexpression of AMPK also prevented loss of insulin signaling in HI- and HP-cultured cardiomyocytes, but did not prevent lipid accumulation
Asrih et al., J Mol Cell Cardiol 2013 : In cardiomyocytes exposed to 1nM CT-1 there was also reduced phosphorylation of Akt and AS160 in response to insulin , and of AMPK in response to oligomycin
Nam et al., Nutrition research and practice 2013 : However, inhibition of AMPK activation attenuated insulin signaling and prevented the stimulation of AMPK target genes
Shibata et al., J Pharmacol Sci 2013 (Diabetes Mellitus, Type 2...) : However, the mechanism by which AMPK regulates insulin signaling remains unclear
Quinn et al., Cancer prevention research (Philadelphia, Pa.) 2013 : Previously, we showed that metformin prevented tobacco carcinogen ( NNK ) -induced lung tumorigenesis in a non-diabetic mouse model, which was associated with decreased IGF-I/insulin receptor signaling but not activation of AMPK in lung tissues, as well as decreased circulating levels of IGF-I and insulin
Makinde et al., Circ Res 1997 : In 1-day-old hearts, the presence of insulin resulted in a significant decrease in AMPK activity, an increase in ACC activity, and a decrease in fatty acid oxidation rates ... These data suggest that AMPK, ACC, and fatty acid oxidation are sensitive to insulin in 1-day-old rabbit hearts and that the decrease in circulating insulin levels seen after birth leads to an increased activity of AMPK