Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Alpert et al., Biochem Pharmacol 2007 : Because PKCdelta has also been shown to activate mTOR, we asked whether COX-2 inhibitors activate mTOR by a prior activation of PKCdelta
de Oliveira et al., Journal of neuroinflammation 2012 : In contrast, the mTOR inhibitor rapamycin enhanced both COX-2 and mPGES-1 immunoreactivity and the release of PGE2 and PGD2 ... Interestingly, NVP-BEZ235, a dual PI3K/mTOR inhibitor, enhanced COX-2 and reduced mPGES-1 immunoreactivity, albeit PGE2 and PGD2 levels were enhanced in LPS stimulated microglia ... Taken together, we demonstrate that blockade of mTOR and/or PI3K/Akt enhances prostanoid production and that PI3K/Akt, GSK-3 and mTOR differently regulate the expression of mPGES-1 and COX-2 in activated primary microglia
Sidahmed et al., Phytomedicine 2013 : In addition, PA exhibited a potent FRAP value and significant COX-2 inhibition