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NFKB1 — PTK2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shames et al., J Surg Res 1999
:
LPS Induced
NF-kappaB activation and TNF-alpha release in human monocytes are
protein tyrosine kinase dependent and protein kinase C independent ...
PTK inhibition with Gen
attenuated both LPS induced
NF-kappaB DNA binding and TNF-alpha production in human monocytes ... Furthermore, our results provide evidence that
PTK plays a role in LPS induced
NF-kappaB activation and TNF-alpha release in human monocytes and thus could be a potential therapeutic target in inflammatory states
Kang et al., J Toxicol Environ Health 2000
:
Specific inhibitors of
protein tyrosine kinase , such as herbimycin A, genistein, and AG-494,
prevented NF-kappaB activation in silica treated cells
Kang et al., Toxicology 2000
:
A specific inhibitor of
protein tyrosine kinase ( PTK ) , genistein,
prevented the
NF-kappaB activation induced by pervanadate in the presence of silica while inhibitors of protein kinase A or C, such as staurosporine or H7, had no inhibitory effect on NF-kappaB activation
Kokura et al., J Vasc Res 2001
:
However, both A/R- and redox induced
NF kappa B activation was blocked by inhibition of
PTK
Kang et al., Mol Cell Biochem 2000
:
Specific inhibitors of
protein tyrosine kinase , such as genistein and AG494,
prevented NF-kappaB activation in SNP- or SIN-1 treated cells, suggesting involvement of tyrosine kinase in the NO signaling pathway leading to NF-kappaB activation
Roebuck et al., J Bone Miner Res 2001
(Osteosarcoma) :
Protein tyrosine kinase ( PTK ) inhibitors, which significantly reduce the suppressive effect of titanium particles on collagen gene expression,
inhibited NF-kappaB binding activity showing that titanium particle stimulation of PTK signals in osteoblasts are critical for both NF-kappaB activation and collagen gene expression
Waris et al., Biochem Pharmacol 2002
(Hepatitis C) :
The inhibitory effect of protein tyrosine kinase ( PTK ) inhibitors indicates the
involvement of
PTK in
NF-kappaB activation by NS5A
Takada et al., J Biol Chem 2003
:
We present several lines of evidence to suggest that the Syk
protein-tyrosine kinase is
involved in H2O2 induced
NF-kappaB activation
Iwasaki et al., FEBS Lett 1992
:
Since a number of growth factors signal via protein tyrosine kinase, in this study we examined a possible
involvement of
protein tyrosine kinase in the IL-1 alpha induced
NF-kappa B
Sumi et al., Yakugaku Zasshi 2007
:
Although IKKbeta activates transcription factor
NF-kappaB and PTP1B negatively
regulates the
receptor-protein tyrosine kinase , such as epidermal growth factor receptor (EGFR) in cells, covalent modification of these proteins caused by 1,2-NQ results in inhibition of NF-kappaB activity and transactivation of EGFR
MacLeod et al., Clinical and vaccine immunology : CVI 2008
:
PorB induced
NF-kappaB nuclear translocation was not
dependent on either
PTK or Erk1/2 activities
Geng et al., J Immunol 1993
:
Both
PTK inhibitors also
reduced the LPS activation of nuclear factor-kappa B
(NF-kappa B) , which is a transcription factor involved in the expression of cytokine genes such as IL-6 and TNF-alpha ... In summary, these findings suggest that protein kinase C and protein kinase A appear to have selective effects in the LPS induction of cytokines, whereas
PTK is
required for LPS induction of a broad spectrum of cytokines and
NF-kappa B activation in monocytes
Trede et al., J Immunol 1993
(Leukemia, Monocytic, Acute) :
Induction of both
NF-kappa B DNA binding proteins and NF-kappa B enhancer function was
down-regulated by inhibitors of protein kinase C and
protein tyrosine kinase , indicating a role for these protein kinases in the induction of NF-kappa B by MHC class II ligands
Umansky et al., Int Immunol 1996
(Newcastle Disease) :
NDV mediated NO synthesis and
NF-kappa B activation were blocked by an antioxidant ( butylated hydroxyanisole ), by an inhibitor of
protein tyrosine kinase ( genistein ) and of protein kinase A ( H-89 ), but not by an inhibitor of protein kinase C ( staurosporin )
Zhu et al., Biochim Biophys Acta 1997
:
The increases of ICAM-1 mRNA and
NF-kappa B binding were
inhibited by the
protein tyrosine kinase inhibitors, genistein and lavendustin A, but not by inhibitors for cyclic AMP dependent protein kinases or protein kinase C
Sodhi et al., Immunol Lett 1998
:
It was observed that cisplatin induced
NF-kappaB translocation
involves serine/threonine phosphatases 1/2A, protein tyrosine phosphatases and genestein sensitive
protein tyrosine kinase activities
Lazaar et al., J Immunol 1998
:
These results delineate a potentially important CD40 mediated signal-transduction pathway in ASM, involving
protein tyrosine kinase dependent calcium mobilization,
NF-kappaB activation, and IL-6 production