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PI3 — PTK2
Text-mined interactions from Literome
Rankin et al., J Biol Chem 1996
:
Furthermore, LY294002, an inhibitor of
PI 3'-kinase structurally unrelated to wortmannin, also
inhibited PDGF stimulated
p125FAK tyrosine phosphorylation ... PDGF stimulated,
PI 3'-kinase dependent tyrosine phosphorylation of
p125FAK was not inhibited by rapamycin, and thus it was dissociated from the activation of p70 S6 kinase, previously identified as a molecular downstream target of PI 3'-kinase
Lebrun et al., J Biol Chem 1998
:
In addition,
pp125(FAK) induced association of IRS-1 with
PI 3-kinase resulted in increased PI 3-kinase activity
Ji et al., Biochim Biophys Acta 1999
:
Integrin alpha IIb beta 3-mediated
pp125FAK phosphorylation and platelet spreading on fibrinogen are
regulated by
PI 3-kinase ... Finally, the
PI 3-kinase inhibitors '
effect on alpha IIb beta 3-mediated spreading and
pp125FAK phosphorylation was reversed by phorbol ester treatment ... These results establish that the role of
PI 3-kinase relative to pp125FAK phosphorylation in platelets is receptor type-specific yet
essential for alpha IIb beta 3-mediated cell spreading and
pp125FAK phosphorylation