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PI3 — PTK2

Text-mined interactions from Literome

Rankin et al., J Biol Chem 1996 : Furthermore, LY294002, an inhibitor of PI 3'-kinase structurally unrelated to wortmannin, also inhibited PDGF stimulated p125FAK tyrosine phosphorylation ... PDGF stimulated, PI 3'-kinase dependent tyrosine phosphorylation of p125FAK was not inhibited by rapamycin, and thus it was dissociated from the activation of p70 S6 kinase, previously identified as a molecular downstream target of PI 3'-kinase
Lebrun et al., J Biol Chem 1998 : In addition, pp125(FAK) induced association of IRS-1 with PI 3-kinase resulted in increased PI 3-kinase activity
Ji et al., Biochim Biophys Acta 1999 : Integrin alpha IIb beta 3-mediated pp125FAK phosphorylation and platelet spreading on fibrinogen are regulated by PI 3-kinase ... Finally, the PI 3-kinase inhibitors ' effect on alpha IIb beta 3-mediated spreading and pp125FAK phosphorylation was reversed by phorbol ester treatment ... These results establish that the role of PI 3-kinase relative to pp125FAK phosphorylation in platelets is receptor type-specific yet essential for alpha IIb beta 3-mediated cell spreading and pp125FAK phosphorylation