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AKT3 — PTX3

Text-mined interactions from Literome

Li et al., Biochem Biophys Res Commun 2001 (MAP Kinase Signaling System) : In addition, PTX induced phosphorylation of Akt and of ERK2, which could be completely blocked by LY294002 and PD098059, respectively, and by genistein or tyrphostin 47 as well
Lin et al., Mol Pharmacol 2003 : PTX blocks Akt but not phosphatidylinositol 3-kinase (PI3K) activation in response to PDGF and abrogates cyclin D1 induction by PI3K, suggesting an effect of PTX on Akt itself ... Indeed, PTX is capable of blocking the membrane translocation of Akt, and enforced targeting of Akt to cell membrane prevents the inhibition of Akt and cyclin D1 by PTX
Wu et al., Cell Signal 2005 : The NGF dependent Akt activation was partially attenuated by PTX or overexpression of regulators of G protein signaling Z1 ( RGSZ1 ) and Galpha interacting protein (GAIP) ), indicating the participation of G ( i/o ) proteins ... Expression of PTX-resistant mutants of Galpha ( i1 ), Galpha ( i3 ), Galpha ( oA ), and Galpha ( oB ), but not Galpha ( i2 ), abolished the inhibitory effect of PTX on NGF induced Akt activation
Zhang et al., Am J Physiol Cell Physiol 2006 : Pertussis toxin ( PTX ) blocks LPA induced activation of p38 and ERK but only slightly inhibits LPA induced activation of Akt
Chiou et al., Pediatr Res 2006 : PTX and wortmannin, a PI3 K inhibitor, not only inhibited the PDGF activated phosphorylation of Akt but also suppressed p70S6 K expression and IkappaBalpha degradation, inhibiting nuclear translocation and the DNA binding activity of NF-kappaB
Bongers et al., J Neurochem 2007 (MAP Kinase Signaling System...) : The H(3)R mediated activation of Akt can be inhibited by the H(3)R inverse agonist thioperamide, and by Wortmannin, LY294002 and PTX , suggesting the observed Akt activation occurs via a G ( i/o ) -mediated activation of phosphoinositide-3-kinase
Endo et al., Int Arch Allergy Immunol 2009 : Although PTX significantly reduced the activation of AKT/PKB and migration, PTX had no effects on degranulation
Barancik et al., International journal of molecular sciences 2012 : In contrast, the presence of VCR eliminated the effects of PTX on Akt kinase phosphorylation
Liu et al., International journal of clinical and experimental pathology 2013 (Atherosclerosis) : Moreover, inhibition of AKT , the downstream effector of ERBB2/3, also reduced PTX-3 expression