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PXN — RHOA

Pathways - manually collected, often from reviews:

• BioCarta ucalpain and friends in cell spread: RhoA (RHOA) → PAX (PXN) (modification, activates)
• KEGG Leukocyte transendothelial migration: RHOA → PXN (protein-protein, indirect effect)
• NCI Pathway Database mTOR signaling pathway: Paxillin (PXN) → RHOA/GTP complex (RHOA) (regulation of actin cytoskeleton organization, collaborate) Sarbassov et al., Curr Biol 2004, Jacinto et al., Nat Cell Biol 2004
  Evidence: mutant phenotype

Text-mined interactions from Literome

Gakidis et al., J Cell Biol 2004 : beta2 induced activation of Cdc42, Rac1, and RhoA is defective in Vav1/3ko neutrophils, and phosphorylation of Pyk2, paxillin , and Akt is also significantly reduced
Lu et al., Mol Pharmacol 2006 : Compared with docetaxel, laulimalide more potently caused a reduction in the constitutive levels ( i.e., in the absence of VEGF ) of phosphorylated paxillin and more potently inhibited the association of RhoA with the alpha5beta1 integrin
Takemura et al., J Periodontol 2006 : Phosphorylation of paxillin and FAK by PDL cells was induced, and RhoA activation also was induced
Shafikhani et al., Cell cycle (Georgetown, Tex.) 2008 : Our data demonstrate that the subcellular localization and the activity of RhoA and citron K, which are essential for early stages of cytokinesis, are not dependent on paxillin , Crk or syntaxin-2
Deakin et al., PloS one 2012 : Paxillin and Hic-5 interaction with vinculin is differentially regulated by Rac1 and RhoA
Zhang et al., J Biol Chem 2012 : We assessed the mechanism by which RhoA regulates actin dynamics and smooth muscle contraction by expressing the dominant negative mutants RhoA T19N and cdc42 T17N, and non-phosphorylatable paxillin Y118/31F and paxillin dLD4 deletion mutants in SM tissues