Gene interactions and pathways from curated databases and text-mining

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MAPK8 — RAF1

Pathways - manually collected, often from reviews:

  • KEGG Hepatitis C: ARAF/BRAF/RAF1 → MAPK10/MAPK8/MAPK9 (protein-protein, activation)
  • WikiPathways Angiopoietin Like Protein 8 Regulatory Pathway: RAF1 → MAP2K1/MAP3K7/MAPK14/MAPK1/MAP2K2/MAP3K2/MAP3K6/MAPK8/MAP4K1/MAP3K11/MAP4K3/MAPK10/MAP2K7/MAP3K4/MAP3K1/MAP3K12/MAPK4/MAPK11/MAP4K5/MAPK6/MAP4K4/MAPK3/MAP3K14/MAPK12/MAP2K5/MAP2K4/MAPK13/MAP3K5/MAPK9/MAPK7/MAP3K3/MAP3K9/MAP3K8/MAP2K6/MAP3K13/MAP4K2/MAP2K3/MAP3K10/MINK1 (activation)
  • WikiPathways Insulin Signaling: RAC1/GRB2/SOS1/RAC2/RRAD/GRB14/SOS2/RAF1/HRAS/GRB10 → MINK1/MAP4K4/MAP3K2/MAPK12/MAP3K5/MAPK10/MAP3K3/MAP4K1/MAPK3/MAP2K7/MAPK13/MAP3K1/MAP4K3/MAP2K6/MAP3K8/MAP3K12/MAP2K4/MAPK7/MAPK14/MAP3K11/MAP3K7/MAPK11/MAPK9/MAPK6/MAP3K13/MAP2K3/MAPK4/MAP4K2/MAP2K5/MAP3K10/MAPK1/MAP2K1/MAP3K6/MAP3K4/MAP3K9/MAP4K5/MAP2K2/MAPK8/MAP3K14 (activation)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Shibayama et al., Blood 1999 : 8-Br-cAMP, Dibutyryl-cAMP, Ras-Raf-1 pathway inhibitors, and PD98059, a MAPK kinase inhibitor , suppressed proliferation and phosphorylation of MAPK detected by Western blotting with anti-phospho-MAPK antibody, but not adhesion of any type of H-Ras transfected Baf3 cells, whereas U-73122, a phospholipase C (PLC) inhibitor, suppressed adhesion of these cells completely
Kalmes et al., FEBS Lett 1999 : We conclude that activation of Raf-1 by SB203580 is not mediated by an inhibition of p38 MAPK , is Ras independent, and is uncoupled from MEK/ERK signaling
Majewski et al., Cancer Res 1999 : Inhibition of plasma membrane Raf-1 dependent mitogen activated protein kinase activity had no effect on the enhanced survival of cells expressing Akt
Samadder et al., Cancer Res 1999 (Breast Neoplasms) : We have previously shown that inhibition of MCF-7 cell proliferation by 1-O-octadecyl-2-O-methyl-glycerophosphocholine ( ET-18-OCH3 ) is linked to a drug induced decrease in membrane Raf-1 levels and the subsequent inhibition of mitogen activated protein ( MAP ) kinase activation in response to growth factor stimulation
Teng et al., J Biol Chem 1999 : We report here that Ras ( C118S ) functions indistinguishably from wild type Ras in activating and maintaining the mSOS1- and Raf-1 dependent mitogen activated protein kinase cascade necessary for neuronal differentiation
Lee et al., Proc Natl Acad Sci U S A 2000 : Finally, activation of MAPK by p53 was inhibited by expression of dominant negative Ras ( N17Ras ) and Raf1 mutants, indicating that MAPK activation by p53 is mediated at a level upstream of Ras
Banihashemi et al., Mol Endocrinol 2002 : These results indicate that the dopamine-D2S receptor couples to distinct G ( i/o ) proteins, depending on the pathway addressed, and suggest a novel Galpha(i)3/Galpha ( o ) -dependent inhibition of MAPK mediated by c-Raf and B-Raf dependent inhibition of MAPK/ERK kinase
Kurokawa et al., Clin Cancer Res 2003 (Breast Neoplasms...) : Aberrant signaling by receptors of the erbB network up-regulates a number of signaling pathways, which include phospholipase C-gamma1, Ras-Raf-mitogen activated protein/extracellular signal regulated kinase kinase-mitogen activated protein kinase , phosphatidylinositol 3'-kinase and its target, the serine/threonine kinase Akt, stress activated protein kinases, signal transducers and activators of transcription, and c-Jun-NH ( 2 ) -terminal kinase ( JNK )
Ostrovsky et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Specific activation of MAPK by expression of an active Raf1-estrogen receptor chimera protein reduced significantly the number of myoblasts undergoing programmed cell death in the differentiation medium
Kyriakis et al., Nature 1992 : These results indicate that c-Raf-1 is an immediate upstream activator of MAPK-K in vivo
Yu et al., Oncogene 2004 (Leukemia) : These events were accompanied by the caspase independent downregulation of Raf-1 , inactivation of MEK1/2, ERK, Akt, p70S6K, dephosphorylation of GSK-3, and activation of c-Jun-N-terminal kinase (JNK) and p38 MAPK
Trakul et al., J Biol Chem 2005 (MAP Kinase Signaling System) : Here, we show that RKIP inhibits MAPK by regulating Raf-1 activation ; specifically, RKIP acts subsequent to Raf-1 membrane recruitment, prevents association of Raf-1 and p21 activated kinase (PAK), and blocks phosphorylation of the Raf-1 kinase domain by PAK and Src family kinases ... Because c-Raf-1 and B-Raf are both required for maximal MAPK stimulation by epidermal growth factor in neuronal and epithelial cell lines, we determined whether RKIP significantly affects MAPK signaling
Tartaglia et al., Molecular syndromology 2010 : SHP2 ( encoded by PTPN11 ), SOS1, BRAF, RAF1 and MEK1 positively contribute to RAS-MAPK signaling, and possess complex autoinhibitory mechanisms that are impaired by mutations
Kharbanda et al., J Biol Chem 1994 (Leukemia, Myeloid) : Since Raf-1 can activate the mitogen activated protein ( MAP ) kinases , we also studied the relationship between MAP kinase activation and monocytic differentiation
Kyriakis et al., J Biol Chem 1993 : Although PDGF/insulin stimulated c-Raf-1 Ser/Thr phosphorylation may be necessary to sustain the active state, a role for mitogen activated protein kinase/extracellular signal regulated kinase-2 phosphorylation in the initiation of c-Raf-1 activation is unlikely
Whitehurst et al., J Immunol 1996 : Active Raf-1 phosphorylates and activates the mitogen activated protein ( MAP ) kinase/extracellular signal regulated kinase kinase 1 ( MEK1 ), which in turn phosphorylates and activates the MAP kinases/extracellular signal regulated kinases, ERK1 and ERK2
Lazarini et al., J Neurochem 1996 : IRL1620 induced MAPK activation involved the adapter proteins Shc and Grb2 and the serine/threonine kinase Raf-1
Radziwill et al., Biochem Biophys Res Commun 1996 : This lipid induced MAPK activation is blocked by a Raf-1 derived peptide comprising Ser259
Pumiglia et al., Proc Natl Acad Sci U S A 1997 : Activation of delta RAF-1 : ER resulted in a prolonged increase in MAPK activity and growth arrest of these cells, with concomitant induction of p21Cip1/WAF1 and inhibition of CDK2 activity
Mazure et al., Blood 1997 (Cell Transformation, Neoplastic...) : In this report, we show Ras transformed cells do not use the downstream effectors c-Raf-1 or mitogen activated protein kinases ( MAPK ) in signaling VEGF induction by hypoxia as overexpression of kinase-defective alleles of these genes does not inhibit VEGF induction under low oxygen conditions
Lu et al., J Neurochem 1998 : Raf-1 dependent activation of mitogen activated protein kinase ( MAPK ) is the key in the chronic norepinephrine neuromodulatory actions of Ang II and is associated with the translocation of MAPK into the nucleus
Hoshino et al., J Biol Chem 1998 (Leukemia, Myeloid) : Thus, LTD4 has at least two distinct signaling pathways in THP-1 cells, a PTX-insensitive mitogen activated protein kinase activation through protein kinase Calpha and Raf-1 and a PTX-sensitive chemotactic response
Greene et al., Eur J Neurosci 1998 : The two FGFs induce an equivalent level of tyrosine phosphorylation of mitogen activated protein kinase ( MAPK ) and c-raf activation
Howe et al., J Biol Chem 1998 : We show that integrin mediated activation of Raf-1 , an upstream regulator of mitogen activated protein kinase , occurs in two phases