Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Narita et al., Science 2011 : mTOR recruitment to the TASCC was amino acid- and Rag guanosine triphosphatase dependent , and disruption of mTOR localization to the TASCC suppressed interleukin-6/8 synthesis
DurĂ¡n et al., Mol Cell 2012 : Constitutively active Rag heterodimer activated mTORC1 in the absence of glutaminolysis
Narita et al., Small GTPases 2012 : Thus, the TASCC provides evidence for the functional relevance of the Rag mediated association between lysosomes and mTOR , and provides a mechanism for the simultaneous activation of anabolic and catabolic processes
Sancak et al., Science 2008 : Conversely, expression of a guanosine diphosphate bound Rag mutant prevented stimulation of mTORC1 by amino acids
Settembre et al., EMBO J 2012 : Interestingly, the Rag GTPase complex, which senses lysosomal amino acids and activates mTORC1 , is both necessary and sufficient to regulate starvation- and stress induced nuclear translocation of TFEB
Sancak et al., Cell 2010 (MAP Kinase Signaling System) : Thus, Rag-Ragulator mediated translocation of mTORC1 to lysosomal membranes is the key event in amino acid signaling to mTORC1