Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Minhajuddin et al., J Immunol 2005 : Inhibition of mTOR by this approach promoted whereas over-expression of mTOR inhibited thrombin induced transcriptional activity of NF-kappaB , an essential regulator of ICAM-1 transcription ... Consistent with these data, we observed a more efficient and stable nuclear localization of RelA/p65 and, subsequently, the DNA binding activity of NF-kappaB by thrombin following mTOR inhibition
Djavaheri-Mergny et al., J Biol Chem 2006 : This repression is associated with an NF-kappaB dependent activation of the autophagy inhibitor mTOR
Brown et al., Ann Clin Lab Sci 2006 (Neoplasms, Squamous Cell...) : Because the mammalian target of the rapamycin (mTOR) pathway contributes to the activation of NF-kappaB through immunophilin/mTOR signaling , we investigated : ( a ) the immunohistochemical expression and state of activation and potential clinical significance of components of the mTOR signal transduction pathway in SCCT patients ( morphoproteomics ) ; and ( b ) the inhibitory effects of rapamycin on the growth and state of activation of mTOR in 2 HNSCC cell lines ( pharmacoproteomics )
Ghosh et al., Cancer Cell 2006 (MAP Kinase Signaling System) : Furthermore, in TSC2 ( -/- ) MEFs, the rapamycin mediated inhibition of deregulated mTOR activity restored NF-kappaB activation and survival
Dan et al., Genes Dev 2008 (Prostatic Neoplasms) : Akt dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK ... We show here that mTOR downstream from Akt controls NF-kappaB activity in PTEN-null/inactive prostate cancer cells via interaction with and stimulation of IKK
Park et al., Cancer Res 2009 (Brain Neoplasms...) : However, unlike other signals that regulate mTOR activity without affecting its level, RIP1 negatively regulates mTOR transcription via a NF-kappaB dependent mechanism
Ahmed et al., Molecular cancer 2010 (Breast Neoplasms) : Moreover, overexpression of mTOR inhibits OPN induced NF-kappaB and AP-1-DNA binding and transcriptional activity