Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Bonneau et al., Mol Biol Rep 2012 : The activation of mTOR is regulated by a small G-protein, Rheb1
Wu et al., Am J Pathol 2013 (Cardiomegaly...) : Cardiomyocyte apoptosis was reduced and mTORC1 activity was suppressed in cardiomyocyte Rheb1-deletion mice, suggesting that Rheb1 regulates mTORC1 activation in myocardium ... This study indicates that Rheb1 is essential for mTORC1 activation in cardiomyocytes and suggests that targeting Rheb1-mTORC1 signaling, such as by As-IV treatment, may be an effective therapeutic method for treating patients with adverse cardiac remodeling after MI and hypertrophy
Sato et al., J Biol Chem 2009 : Both Rheb1 and Rheb2 activate mTORC1
Zou et al., Dev Cell 2011 : Rheb1 is required for mTORC1 and myelination in postnatal brain development ... Our study demonstrates that Rheb1 is essential for mTORC1 signaling and myelination in the brain, and suggests that mTORC1 signaling plays a role in selective cellular adaptations, rather than general cellular viability