◀ Back to AKT3
AKT3 — RNF19A
Text-mined interactions from Literome
Marushige et al., Anticancer Res 1999
(MAP Kinase Signaling System...) :
The
p38 inhibitor, PD169316,
reduced the activities of ERK and
Akt
Bijur et al., J Neurochem 2000
:
Akt activation was not blocked by inhibition of
p38 or ERK1/2, indicating the independence of these signaling systems
Gratton et al., J Biol Chem 2001
:
Conversely, activation-deficient
Akt decreases VEGF stimulated MEKK3 phosphorylation and
increases MKK/p38 activation
Souza et al., Mol Med 2001
(MAP Kinase Signaling System) :
Interestingly, however, SB203580, a known
p38 inhibitor, completely
inhibited arsenite induced phosphorylation of
AKT and eNOS
Kettritz et al., J Am Soc Nephrol 2002
:
p38 MAPK inhibition with 10 microM SB202190 that also decreased ANCA induced superoxide generation
prevented S473 phosphorylation of
Akt in response to TNF-alpha and to ANCA
Baudhuin et al., Mol Pharmacol 2002
:
However, epidermal growth factor, thrombin, and endothelin-1 stimulated
Akt S473 phosphorylation
require p38 but not MEK ... MEK and
p38 activation were
sufficient for
Akt S473 but not T308 phosphorylation in HEY cells
Gonzalez et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
Inhibition or activation of
p38 with SB203580, dominant negative p38, or MKK6EE
regulated Akt kinase activity
Taniyama et al., Am J Physiol Cell Physiol 2004
(MAP Kinase Signaling System) :
Inhibition of
p38 MAPK activity with SB-203580 dose-dependently
inhibits Akt phosphorylation on Ser ( 473 ), but not Thr ( 308 )
Grethe et al., Biochem Biophys Res Commun 2006
:
Notably, we also found that doxorubicin provoked apoptosis included
p38 MAPK
mediated inhibition of
Akt and Bad phosphorylation
Liu et al., J Biol Chem 2007
(Insulin Resistance) :
Our results show that a prolonged treatment of primary hepatocytes with oleate blunted insulin suppression of hepatic gluconeogenesis, and decreased insulin induced phosphorylation of
Akt in a
p38 dependent manner
Diehl et al., J Surg Res 2007
(Breast Neoplasms...) :
We also found that
AKT was
activated by
p38MAPK in these cells, but this activation did not play a role in invasion
Ogunwobi et al., Am J Gastroenterol 2008
(Adenocarcinoma...) :
Simvastatin
inhibited activation of extracellular signal regulated kinase ( ERK ) and protein kinase B (
Akt ) but not c-Jun NH ( 2 ) -terminal kinase or
p38 mitogen activated protein ( MAP ) kinase
Hong et al., J Exp Clin Cancer Res 2009
(Carcinoma, Squamous Cell...) :
Inhibition of
Akt activity by PIA decreased NF-kappaB signaling, but did not
affect phosphorylation of ERK, JNK, and
p38 in KB and KOSCC-25B cells
Rane et al., American journal of physiology. Renal physiology 2010
(Diabetes Mellitus, Experimental...) :
These results collectively suggest that downregulation of
Akt activation during long-term hyperglycemia
contributes to enhanced
p38 MAPK activation and RPTC apoptosis
Bulzomi et al., IUBMB Life 2010
(Neoplasms, Hormone-Dependent) :
In contrast, Nar stimulation prevents E2-induced extracellular regulated kinases ( ERK1/2 ) and
AKT activation and still
induces the activation of
p38 , the proapoptotic member of mitogen activating protein kinase ( MAPK ) family
Aceros et al., Br J Pharmacol 2011
(Fibrosis...) :
In vitro, moxonidine inhibited norepinephrine induced neonatal cardiomyocyte mortality but increased fibroblast mortality, through I ( 1 ) -receptor activation and differential
effects on downstream
Akt and
p38 MAPK
Valente et al., Cell Signal 2012
(Fibrosis...) :
These results indicate that IL-17A stimulates CF proliferation and migration via
Akt/miR-101/MKP-1 dependent
p38 MAPK and ERK1/2 activation
Suwanabol et al., Am J Physiol Heart Circ Physiol 2012
(Carotid Artery Injuries) :
Furthermore, inhibition of
p38 in vivo
led to decreased
Akt phosphorylation and SMC proliferation
Yamawaki et al., Biochem Biophys Res Commun 2012
(Inflammation) :
The effect is mediated via inhibiting
activation of NF-?B and
p38 through stimulation of
Akt/eNOS signaling and NO production