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RPTOR — SREBF1

Pathways - manually collected, often from reviews:

• NCI Pathway Database mTOR signaling pathway: mTORC1 complex (MTOR-MLST8-RPTOR) → SREBP1 (SREBF1) (translocation, activates) Porstmann et al., Cell Metab 2008*
  Evidence: mutant phenotype, assay

Text-mined interactions from Literome

Wong et al., Curr Opin Pharmacol 2010 (Metabolic Diseases) : SREBP-1c can be induced by mTORC1 , bifurcating lipogenesis from AKT activated gluconeogenesis
Yecies et al., Cell Metab 2011 : To further define the role of mTORC1 in the regulation of SREBP1c in the liver, we generated mice with liver-specific deletion of TSC1 ( LTsc1KO ), which results in insulin independent activation of mTORC1 ... Therefore, mTORC1 activation is not sufficient to stimulate hepatic SREBP1c in the absence of Akt signaling, revealing the existence of an additional downstream pathway also required for this induction
Bakan et al., Curr Opin Lipidol 2012 : Recent studies indicate that mTORC1 regulates SREBP-1 activation at multiple levels