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IL6 — S100A8
Text-mined interactions from Literome
Jacobs et al., Skin Pharmacol Physiol 2004
(Warts) :
Analysis of imiquimod treated warts demonstrated that imiquimod enhanced
IL-6 expression and
induced IL-8, GM-CSF,
MRP-8 and MRP-14
Schelbergen et al., Arthritis Rheum 2012
(Osteoarthritis) :
Stimulation of chondrocytes with
S100A8 and S100A9
caused a strong up-regulation of catabolic markers ( MMPs 1, 3, 9, and 13,
interleukin-6 [ IL-6 ], IL-8, and monocyte chemotactic protein 1 ) and down-regulation of anabolic markers ( aggrecan and type II collagen ), thereby favoring cartilage breakdown
Abbas et al., Stroke 2012
(Carotid Artery Diseases...) :
Our main findings were : ( 1 ) plasma levels of S100A12 were significantly higher in patients with carotid atherosclerosis compared with healthy control subjects with the highest levels in patients with the most recent symptoms ( ie, within 2 months ) ; ( 2 ) plasma levels of S100A8/S100A9 showed a modest increase in patients with symptoms in the previous 2 to 6 months but not in the other patients ; ( 3 ) mRNA levels of S100A8, S100A9, and S100A12 showed increased expression in atherosclerotic carotid plaques from patients with the most recent symptoms compared with the remaining patients ; ( 4 ) in THP-1 monocytes, activation of Toll-like receptors 2 and 4 increased mRNA levels of
S100A8 , S100A9, and S10012 and
interleukin-1ß , interferon ?, and releasate from thrombin activated platelets significantly
enhanced the expression of S100A12
Kim et al., Biochem Biophys Res Commun 2012
(Colorectal Neoplasms...) :
The upregulation of
S100A8/A9 in tumor infiltrated myeloid cells could be
triggered by
IL-6 and IL-8 released from myofibroblasts, and myofibroblasts might induce the differentiation of myeloid cells into S100A8/9 expressing MDSCs or M2 macrophages in the CRC microenvironment