◀ Back to IFNG
IFNG — SCG2
Text-mined interactions from Literome
Matsuse et al., Ann Allergy Asthma Immunol 1999
(Asthma...) :
We compared the
effects of
SCG on interleukin (IL)-5 and
interferon (IFN)-gamma production by sensitized PBMCs with that of dexamethasone ( Dex )
Harada et al., J Interferon Cytokine Res 2002
:
In this study, we examined
interferon-gamma (IFN-gamma) induction by
SCG from splenocytes in DBA/2 mice in vitro ... In the splenocytes derived from almost all inbred strains of mice except for DBA/1 and DBA/2 mice,
IFN-gamma production was not
induced by
SCG ... The breeder and genders of DBA/2 mice showed no influence on
IFN-gamma induction by
SCG ...
IFN-gamma was
induced by
SCG in adherent splenocytes, but IFN-gamma production was most significantly increased by SCG in instances involving coexistence of adherent and nonadherent splenocytes ... It was suggested that soluble factors and cell-cell contact mediate synergistic effects on
SCG induced
IFN-gamma production
Harada et al., J Interferon Cytokine Res 2004
:
The addition of recombinant murine GM-CSF ( rMuGM-CSF ) to spleen cell cultures from various strains of mice synergistically enhanced
IFN-gamma , TNF-alpha and IL-12p70 in the
presence of
SCG
Harada et al., J Interferon Cytokine Res 2006
:
We recently found that the splenocytes from naive DBA/1 and DBA/2 mice are potently
induced by
SCG to produce interferon- gamma
(IFN-gamma) , tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and interleukin-12p70 (IL-12p70), and that GM-CSF plays a key biologic role among these cytokines ... Neutralization of IL-12 significantly inhibited the
induction of
IFN-gamma by
SCG
Harada et al., Microbiol Immunol 2006
(Leukopenia) :
The levels of
interferon-(IFN-)gamma , tumor necrosis factor-(TNF-)alpha, granulocyte-macrophage-colony stimulating factor ( GM-CSF ), interleukin-(IL-) 6 and IL-12p70 were significantly
increased by
SCG in CY-treated mice ... Neutralizing GM-CSF significantly inhibited the
induction of
IFN-gamma , TNF-alpha and IL-12p70 by
SCG