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FGF2 — SDC1

Pathways - manually collected, often from reviews:

• Reactome Reaction: FGF2 → SDC1 (direct_complex) Steinfeld et al., J Cell Biol 1996*
• Reactome Reaction: FGF2 → SDC1 (reaction) Steinfeld et al., J Cell Biol 1996*

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SDC1 — FGF2 (association, biochemical) Ma et al., J Cell Biol 2006*
• IRef Hprd Interaction: SDC1 — FGF2 (in vitro) Ma et al., J Cell Biol 2006*

Text-mined interactions from Literome

Bodo et al., Eur J Cell Biol 1999 (Craniofacial Dysostosis) : A regulatory role of fibroblast growth factor in the expression of decorin, biglycan, betaglycan and syndecan in osteoblasts from patients with Crouzon 's syndrome
Jaakkola et al., Prog Nucleic Acid Res Mol Biol 1999 : In fibroblasts syndecan-1 is induced by FGF-2 and in keratinocytes by epidermal growth factor (EGF) and keratinocyte growth factor (KGF)
Pursiheimo et al., Proc Natl Acad Sci U S A 2000 : The PKA-specific inhibitor H-89 ( N- [ 2- ( p-bromocinnamylamino ) ethyl ] -5-isoquinolinesulfonamide ) blocked the FGF-2 induced activation of FiRE, the transcription of the syndecan-1 gene, and cell proliferation ... Also, expression of a dominant negative form of PKA inhibited the FGF-2 induced FiRE activation and the transcription of the syndecan-1 gene
Jaakkola et al., Biochem Biophys Res Commun 2000 : Proximal promoter independent activation of syndecan-1 gene by FGF-2 might be required during development when syndecan-1 proximal promoter needs to be largely attenuated but simultaneous transient and rapid FGF-2 induced transcription is required
Worapamorn et al., J Cell Physiol 2001 : Syndecan-1 mRNA levels increased in response to serum, bFGF and PDGF-BB, but decreased in response to TGF-beta1, IL-1beta and IFN-gamma
Qiao et al., J Biol Chem 2003 (Glioma...) : In contrast, overexpression of syndecan-1 had no effect on growth or FGF2 sensitivity
Velleman et al., Poult Sci 2007 : This result indicates that FGF2 responsiveness was not affected by the overexpression of syndecan-1 , syndecan-4, and glypican-1 during differentiation ... This result indicates that FGF2 responsiveness was not affected by the overexpression of syndecan-1, syndecan-4 , and glypican-1 during differentiation
Shimabukuro et al., Matrix Biol 2008 : However, reverse transcription-polymerase chain reaction data ( RT-PCR ) revealed that FGF-2 marginally reduced the gene expression of syndecan-1 , -2, and -4, and did not alter the level of syndecan-3 mRNA
Ruohola et al., Endocrinology 1995 (Mammary Neoplasms, Experimental) : FGF-2 also down-regulated the expression of syndecan-1 , a heparan sulfate proteoglycan that binds FGF with low affinity
Larraín et al., J Biol Chem 1997 : Basic fibroblast growth factor and transforming growth factor type beta, which are inhibitors of myogenesis, had little effect on syndecan-1 expression
Filla et al., J Cell Physiol 1998 (Burkitt Lymphoma) : The cell surface proteoglycan syndecan-1 mediates fibroblast growth factor-2 binding and activity