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CD4 — SEA

Text-mined interactions from Literome

Kell et al., Shock 1999 (Burns...) : We also observed a novel injury dependent switch from CD4+ to CD8+ T-cells as the dominant T-cell type producing TNFalpha and IFNgamma in response to SEA stimulation in vitro
Lundy et al., Infect Immun 2001 (Granuloma...) : Granuloma formation around schistosomal eggs is induced by soluble egg antigens (SEA) and mediated by the activity of CD4 ( + ) Th lymphocytes and their cytokines ... In culture, SEA induced splenic and granuloma CD4 ( + ) T-cell apoptosis and stimulated expression of FasL on splenic but not granuloma CD4 ( + ) T cells, CD8 ( + ) T cells, and CD19 ( + ) B cells
Shannon et al., Int Immunopharmacol 2002 : In the thalidomide treated SEA stimulated CD4+ and CD8+ cells, thalidomide acted as a costimulant to enhance the synthesis of IL-2
Shainheit et al., Infect Immun 2007 (Inflammation...) : SEA stimulated bulk mesenteric lymph node cells or CD4 T cells from 7-week infected WSX-1 ( -/- ) mice produced significantly less IFN-gamma than did those from C57BL/6 mice, even though there was no difference between these mice in exacerbated hepatic egg induced granulomatous inflammation or in the levels of IL-17 induced by immunization with SEA/CFA
Burton et al., Eur J Immunol 2010 : SEA was able to enhance CD4 ( + ) T-cell secretion of bioactive TGF-ß in response to TLR2 ligand stimulation, in the absence of APC
Oliveira-Prado et al., BMC infectious diseases 2012 (Schistosomiasis mansoni) : The data indicate that SEA stimulated CD4 ( + ) T cells from infected patients have a lower proliferation rate than the same cells from the NI group
Vingerhoets et al., Clin Exp Immunol 1998 (HIV Infections) : Proliferation and IL-2R alpha up-regulation on SEA stimulated CD4+ and CD8+ T cells in whole blood were reduced in HIV+ subjects with CD4 counts < 500, compared with controls