Gene interactions and pathways from curated databases and text-mining

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SIN3A — TP53

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Koumenis et al., Mol Cell Biol 2001 (Cell Transformation, Neoplastic) : At the molecular level, DNA damage induces the interaction of p53 with the transcriptional activator p300 as well as with the transcriptional corepressor mSin3A ... In contrast, hypoxia primarily induces an interaction of p53 with mSin3A , but not with p300
Xu et al., J Biol Chem 2007 : The activity of p53 is differentially regulated by Brm- and Brg1 containing SWI/SNF chromatin remodeling complexes
Zhang et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Researches have shown that ING2 can activate p53 and p53 mediated apoptotic pathway involved in the hepatocarcinogenesis
Madapura et al., Cell cycle (Georgetown, Tex.) 2012 : Modifying p53 levels using Nutlin-3, which specifically dissociates the MDM2-p53 interaction, was sufficient to upregulate SAP expression, indicating that SAP is a target of p53 in T cells