Gene interactions and pathways from curated databases and text-mining

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NEUROD1 — SIRT1

Text-mined interactions from Literome

Hisahara et al., Proc Natl Acad Sci U S A 2008 : The number of neurospheres that generated Tuj1 ( + ) neurons was significantly decreased by pharmacological inhibitors of SIRT1, dominant negative SIRT1 and SIRT1-siRNA, whereas overexpression of SIRT1 , but not that of cytoplasm localized mutant SIRT1, enhanced neuronal differentiation and decreased Hes1 expression ... Expression of SIRT1-siRNA impaired neuronal differentiation and migration of NPCs into the cortical plate in the embryonic brain
Wallenborg et al., Exp Cell Res 2009 : Here we show that relatively low concentrations of resveratrol ( 0.5-3 microM ) specifically inhibited neuronal differentiation of neural stem cells in a SIRT1 dependent manner whereas higher concentrations of resveratrol ( > or =10 microM ) induced a SIRT1 independent cell death
Teng et al., Differentiation 2009 : Sirt1 upregulated by CNS inflammation may also inhibit neuronal differentiation
Aranha et al., PloS one 2011 : Our results provide new insight into the molecular mechanisms by which miR-34a modulates neural differentiation, suggesting that miR-34a is required for proper neuronal differentiation , in part, by targeting SIRT1 and modulating p53 activity
Donmez et al., EMBO Mol Med 2013 (Nerve Degeneration...) : We also cover the role of SIRT1 in neuronal differentiation due to the possible implications in neurodegenerative conditions, and conclude with an outlook on the potential therapeutic value of SIRT1 and SIRT2 in these disorders