Gene interactions and pathways from curated databases and text-mining

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HSP90AA1 — SNX4

Text-mined interactions from Literome

Okawa et al., Blood 2009 (Leukemia...) : SNX-2112 , a selective Hsp90 inhibitor , potently inhibits tumor cell growth, angiogenesis, and osteoclastogenesis in multiple myeloma and other hematologic tumors by abrogating signaling via Akt and ERK
Zhai et al., J Pharm Biomed Anal 2010 : Determination of SNX-2112 , a selective Hsp90 inhibitor , in plasma samples by high-performance liquid chromatography and its application to pharmacokinetics in rats
Bachleitner-Hofmann et al., Clin Cancer Res 2011 : The aim of our study was to assess the efficacy of SNX-2112 , a synthetic HSP-90 inhibitor , in 3 different MET amplified tumor cell lines ( GTL-16, MKN-45, and EBC-1 ) as well as PR-GTL-16 cells, a GTL-16 subline selected for resistance to the highly selective MET kinase inhibitor PHA-665752
Zhai et al., Biomed Pharmacother 2011 : Preclinical pharmacokinetic analysis of SNX-2112 , a novel Hsp90 inhibitor , in rats