UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

SOCS1 — SOCS3

Pathways - manually collected, often from reviews:

BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → SOCS1 (modification, inhibits)
BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → SOCS1 (modification, inhibits)
BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → SOCS1 (modification, inhibits)
BioCarta il-2 receptor beta chain in t cell activation: SOCS3 → SOCS1 (modification, inhibits)
NCI Pathway Database IL2-mediated signaling events: IL2R gamma/JAK3/SOCS1 complex (IL2RG-JAK3-SOCS1) → IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) (modification, inhibits)
Delespine-Carmagnat et al., FEBS Lett 1999, Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Takeshita et al., J Immunol 1992, Asao et al., FEBS Lett 1992, Takeshita et al., Science 1992, Arima et al., J Immunol 1991, Hatakeyama et al., Science 1991, Asao et al., J Exp Med 1990, Mills et al., J Biol Chem 1990, Hatakeyama et al., Cell 1989, Sharon et al., Science 1986, Goldsmith et al., J Biol Chem 1995, Boussiotis et al., Science 1994, Russell et al., Science 1994, Miyazaki et al., Science 1994, Beadling et al., EMBO J 1994, Rebollo et al., Immunology 1993, Lai et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Endo et al., Nature 1997, Liu et al., Curr Biol 1997, Zhou et al., Proc Natl Acad Sci U S A 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species
NCI Pathway Database IL2-mediated signaling events: IL2R beta/JAK1/LCK/SOCS3 complex (IL2RB-JAK1-LCK-SOCS3) → IL2R beta/JAK1/LCK/SOCS1 complex (IL2RB-JAK1-LCK-SOCS1) (modification, inhibits)
Cohney et al., Mol Cell Biol 1999, Aman et al., J Biol Chem 1999, Delespine-Carmagnat et al., Eur J Immunol 2000, Gilmour et al., Proc Natl Acad Sci U S A 1995, Gaffen et al., Proc Natl Acad Sci U S A 1995, Johnston et al., Proc Natl Acad Sci U S A 1995, Hou et al., Immunity 1995, Lin et al., Immunity 1995, Fujii et al., Proc Natl Acad Sci U S A 1995, Wakao et al., EMBO J 1995, Beadling et al., EMBO J 1994, Friedmann et al., Proc Natl Acad Sci U S A 1996, Gaffen et al., J Biol Chem 1996, Liu et al., Curr Biol 1997, Fujii et al., EMBO J 1998
Evidence: mutant phenotype, assay, reporter gene, physical interaction, other species

Text-mined interactions from Literome

Stark et al., J Neuroimmunol 2004 (Encephalomyelitis, Autoimmune, Experimental) : Treatment with conditioned medium from myelin basic protein stimulated encephalitogenic lymphoid cells ( MBP-CM ) increased SOCS-3 and induced SOCS-1 expression
McGillicuddy et al., J Biol Chem 2009 (Insulin Resistance) : IFNgamma induced robust STAT1 phosphorylation and SOCS1 mRNA expression, with modest, transient STAT3 phosphorylation and SOCS3 induction
Wada et al., Am J Physiol Endocrinol Metab 2011 (Insulin Resistance) : IFN-ß preferentially induced SOCS1 rather than SOCS3, whereas IFN-? strongly induced SOCS3 expression alone
Park et al., J Allergy Clin Immunol 2013 (Nasal Polyps...) : SOCS1 was induced by IL-4, IL-13, IFN-?, and TNF-a, while SOCS3 expression was upregulated by IL-6, IL-13, IFN-?, and TNF-a
Suzuki et al., Oncogene 1998 (Leukemia, Myeloid, Acute) : In M1 myeloid leukemia cells, CIS3 was induced by neither interleukin 6 (IL6) nor interferon gamma (IFNgamma), while JAB was induced strongly by IFNgamma and slightly by IL6 and leukemia inhibitory factor (ILF)