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IL10 — SPP1

Text-mined interactions from Literome

Koguchi et al., Infect Immun 2002 (AIDS-Related Opportunistic Infections) : Penicillium marneffei causes osteopontin mediated production of interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002 (Ossification, Heterotopic) : In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ), interleukin (IL)-1beta , and thyroid hormone ( T3 ) induced osteopontin and MMP-13 expression
Isoda et al., Circulation 2003 (Arteriosclerosis...) : CONCLUSIONS : The expression of OPN induces fatty-streak lesion formation in mice fed an atherogenic diet and inhibits IL-10 production by macrophages, thus suggesting that OPN plays an important role in the development of fatty-streak lesions in vivo
Konno et al., J Interferon Cytokine Res 2006 : We report herein a contrasting role of interleukin-10 (IL-10) and Th2 cytokines in the regulation of OPN expression in human monocytes and monocyte derived DCs ( Mo-DCs ) ... Our results showed first that the expression of OPN in monocytes and Mo-DCs was induced in a time dependent and dose dependent manner by IL-10 but was inhibited by IL-4 or IL-13
Mas et al., Mult Scler 2007 (Genetic Predisposition to Disease...) : OPN enhances the production of the pro-inflammatory cytokines, interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Agnholt et al., Scand J Immunol 2007 (Crohn Disease) : The in vitro effect of OPN stimulation on T-cell IFN-gamma, TNF-alpha, and IL-10 production was measured ... OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and TNF-alpha production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ), but induced a concomitant higher IL-10 production in HC than CD ... In vitro, OPN stimulated IL-10 production increases less in T-cell cultures from CD patients than from HC, indicating that IL-10 deficiency may be involved in the defect immune-regulation in CD, even after OPN stimulation
Gao et al., Neoplasia (New York, N.Y.) 2007 (Mammary Neoplasms, Experimental...) : OPN regulates cell adhesion, chemotaxis, macrophage directed IL-10 suppression, stress dependent angiogenesis, apoptosis prevention, and anchorage independent growth of tumor cells
Murugaiyan et al., J Immunol 2008 (Encephalomyelitis, Autoimmune, Experimental...) : There was increased expression of Opn receptor on T cells, and Opn induced IL-17 production by CD4 ( + ) T cells via the beta ( 3 ) integrin receptor and Opn inhibited IL-10 production via the CD44 receptor
Diao et al., Cytokine 2012 (Drug-Induced Liver Injury...) : Osteopontin regulates interleukin-17 production in hepatitis
Sun et al., Cell Mol Immunol 2013 (Breast Neoplasms) : All OPN transcripts significantly inhibited TNF-a and enhanced IL-10 production by monocytes ... Using neutralizing antibody and recombinant cytokines, we found that OPN overexpressed by tumor cells regulates the production of TNF-a and IL-10 by monocytes partly via MCP-1 and TGF-ß1, respectively
Singh et al., J Biol Chem 1995 : In vitro, interleukin-1 beta and interferon-gamma increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes