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IL10 — SPP1
Text-mined interactions from Literome
Koguchi et al., Infect Immun 2002
(AIDS-Related Opportunistic Infections) :
Penicillium marneffei causes
osteopontin mediated production of
interleukin-12 by peripheral blood mononuclear cells
Himeno et al., J Bone Miner Res 2002
(Ossification, Heterotopic) :
In primary culture of Cbfa1-/- chondrocytes, transforming growth factor (TGF) beta1, platelet derived growth factor ( PDGF ),
interleukin (IL)-1beta , and thyroid hormone ( T3 )
induced osteopontin and MMP-13 expression
Isoda et al., Circulation 2003
(Arteriosclerosis...) :
CONCLUSIONS : The expression of
OPN induces fatty-streak lesion formation in mice fed an atherogenic diet and
inhibits IL-10 production by macrophages, thus suggesting that OPN plays an important role in the development of fatty-streak lesions in vivo
Konno et al., J Interferon Cytokine Res 2006
:
We report herein a contrasting
role of
interleukin-10 (IL-10) and Th2 cytokines in the regulation of
OPN expression in human monocytes and monocyte derived DCs ( Mo-DCs ) ... Our results showed first that the expression of
OPN in monocytes and Mo-DCs was
induced in a time dependent and dose dependent manner by
IL-10 but was inhibited by IL-4 or IL-13
Mas et al., Mult Scler 2007
(Genetic Predisposition to Disease...) :
OPN enhances the production of the pro-inflammatory cytokines,
interleukin-12 and interferon-gamma, while reducing interleukin-10 levels
Agnholt et al., Scand J Immunol 2007
(Crohn Disease) :
The in vitro
effect of
OPN stimulation on T-cell IFN-gamma, TNF-alpha, and
IL-10 production was measured ...
OPN increased CD69 and CD25 expression and enhanced T-cell IFN-gamma and TNF-alpha production in a dose dependent fashion with higher levels in CD than in healthy controls ( HC ), but
induced a concomitant higher
IL-10 production in HC than CD ... In vitro,
OPN stimulated
IL-10 production increases less in T-cell cultures from CD patients than from HC, indicating that IL-10 deficiency may be involved in the defect immune-regulation in CD, even after OPN stimulation
Gao et al., Neoplasia (New York, N.Y.) 2007
(Mammary Neoplasms, Experimental...) :
OPN regulates cell adhesion, chemotaxis, macrophage directed
IL-10 suppression, stress dependent angiogenesis, apoptosis prevention, and anchorage independent growth of tumor cells
Murugaiyan et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
There was increased expression of Opn receptor on T cells, and Opn induced IL-17 production by CD4 ( + ) T cells via the beta ( 3 ) integrin receptor and
Opn inhibited
IL-10 production via the CD44 receptor
Diao et al., Cytokine 2012
(Drug-Induced Liver Injury...) :
Osteopontin regulates
interleukin-17 production in hepatitis
Sun et al., Cell Mol Immunol 2013
(Breast Neoplasms) :
All
OPN transcripts significantly inhibited TNF-a and
enhanced IL-10 production by monocytes ... Using neutralizing antibody and recombinant cytokines, we found that
OPN overexpressed by tumor cells
regulates the production of TNF-a and
IL-10 by monocytes partly via MCP-1 and TGF-ß1, respectively
Singh et al., J Biol Chem 1995
:
In vitro,
interleukin-1 beta and interferon-gamma
increased osteopontin mRNA levels in CMEC as well as NOS2 expression in both CMEC and cardiac myocytes