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PLD2 — SYK

Pathways - manually collected, often from reviews:

• KEGG Fc gamma R-mediated phagocytosis: SYK → PLD1/PLD2 (protein-protein, activation)

Text-mined interactions from Literome

Hitomi et al., FEBS Lett 1999 : Cross linking of the B cell receptor induces activation of phospholipase D through Syk , Btk and phospholipase C-gamma2 ... These results demonstrate that Syk , Btk and PLC-gamma2 are essential for BCR induced PLD activation
Hitomi et al., Blood 2004 : However, FcepsilonRI induced PLD activation required Syk and was downstream of the Ca ( 2+ ) response, suggesting that basal PLD1 activity rather than that activated by cell stimulation controlled these early signaling events
Lee et al., Blood 2006 : Phospholipase D2 acts as an essential adaptor protein in the activation of Syk in antigen stimulated mast cells ... Here we show that PLD2 associates with and promotes activation of Syk , a key enzyme in mast cell activation