Gene interactions and pathways from curated databases and text-mining

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BDNF — TCF25

Text-mined interactions from Literome

Tao et al., Neuron 2002 : A calcium-responsive transcription factor , CaRF, that regulates neuronal activity dependent expression of BDNF
Tong et al., J Neurosci 2004 (Alzheimer Disease...) : The effect of sublethal Abeta ( 1-42 ) on BDNF signaling results in the suppression of the activation of critical transcription factor cAMP response element binding protein and Elk-1 and cAMP response element mediated and serum response element mediated transcription
Tabuchi et al., Biol Pharm Bull 2008 (Synaptic Transmission) : Transcriptional activation of the BDNF gene is commonly regulated by a key transcription factor , cAMP response element binding protein ( CREB ), and this at least in part contributes to neuronal activity dependent neuronal survival
Chen et al., Hippocampus 2009 : Utilizing a mouse model genetically engineered with an inducible CREB repressor, our current study provides evidence that increases in BDNF expression and cellular survival signaling resulting from physical exercise are also dependent upon activation of this central transcription factor
Finsterwald et al., J Biol Chem 2010 (MAP Kinase Signaling System) : In this study, we show that the MAPK signaling pathway and the transcription factor cAMP response element binding protein ( CREB ) mediate the effects of BDNF on dendritic length and complexity
Kokaia et al., Exp Neurol 1995 (Brain Injuries...) : The lack of response of the BDNF gene in the ischemic core may be due to suppression of signal transduction or transcription factor synthesis caused by the ischemia