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INS — TGFA
Text-mined interactions from Literome
Sivaprasad et al., Endocrinology 2004
(MAP Kinase Signaling System) :
Stimulation of
insulin-like growth factor (IGF) binding protein-3 synthesis by IGF-I and
transforming growth factor-alpha is mediated by both phosphatidylinositol-3 kinase and mitogen activated protein kinase pathways in mammary epithelial cells
Pignataro et al., Mol Endocrinol 1990
(Leydig Cell Tumor...) :
The experiments presented herein show that insulin,
insulin-like growth factor-I, and
transforming growth factor-alpha increase the labeling of PI-3,4-P2 in MA-10 cells, but only transforming growth factor-alpha mimics the actions of mEGF on the differentiated functions of MA-10 cells
Chen et al., J Invest Dermatol 1995
:
Our results indicate the following : ( 1 ) EGF caused a dramatic potentiation of the 1,25 ( OH ) 2 D3-induced inhibition of 3H-thymidine incorporation into keratinocytes in a dose dependent manner ; ( 2 )
insulin acted antagonistically on the EGF dependent potentiation of the 1,25 ( OH ) 2D3 induced antiproliferative activity ; ( 3 )
transforming growth factor-alpha potentiated 1,25 ( OH ) 2D3 induced antiproliferative activity similar to EGF ; ( 4 ) the EGF effect was not dependent upon 1,25 ( OH ) 2D3 receptor mRNA up-regulation ; and ( 5 ) removal of insulin from medium supplemented with growth factors significantly potentiated the 1,25 ( OH ) 2D3 induced inhibition on the number of basal cells and the 1,25 ( OH ) 2D3 dependent cornified envelope formation