Gene interactions and pathways from curated databases and text-mining

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Text-mined interactions from Literome

Ha et al., Cardiovasc Res 2005 (Cardiomegaly...) : Our results demonstrate that TLR4 is a novel receptor contributing to the development of cardiac hypertrophy in vivo and that both the TLR4 mediated pathway and PI3K/Akt/mTOR signaling are involved in the development of cardiac hypertrophy in vivo
Schmitz et al., Eur J Immunol 2008 : Here we demonstrate that TLR activate mTOR via phosphoinositide 3-kinase/Akt
Yu et al., Acta Biochim Biophys Sin (Shanghai) 2011 (Atherosclerosis) : Toll-like receptor 4 is up-regulated by mTOR activation during THP-1 macrophage foam cells formation ... The mTOR inhibitor rapamycin blocked mTOR phosphorylation and inhibited TLR4 expression induced by ox-LDL ... Inhibition of ox-LDL induced mTOR activation reduced TLR4 expression, and improved the impaired lipid efflux
Brown et al., J Biol Chem 2011 (Inflammation) : Mammalian target of rapamycin complex 2 ( mTORC2 ) negatively regulates Toll-like receptor 4-mediated inflammatory response via FoxO1