Gene interactions and pathways from curated databases and text-mining

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IGF1 — TNFRSF11B

Text-mined interactions from Literome

Rubin et al., J Clin Endocrinol Metab 2002 : IGF-I regulates osteoprotegerin (OPG) and receptor activator of nuclear factor-kappaB ligand in vitro and OPG in vivo ... The half maximal inhibitory dose of IGF-I was reached at 50 micro g/liter ( approximately 6.5 nM ) with no effect of IGF-I on OPG message stability ... In summary, we conclude that IGF-I in a dose- and time dependent manner regulates OPG and RANKL in vitro and in vivo
Katopodis et al., Anticancer Res 2009 (Bone Neoplasms...) : The enhancement of the OPG expression in PC-3 cells by MG-63 cells is not mediated by IGF-1 , IL-6 and TGFbeta1