Gene interactions and pathways from curated databases and text-mining

◀ Back to NOS2

NOS2 — TNFRSF1A

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Alexander et al., Neurochem Int 2008 (Brain Diseases, Metabolic...) : Furthermore, absence of TNFR1 partially but significantly reduced the activation of astrocytes, as shown by immunofluorescence and markedly inhibited iNOS mRNA expression ( p < 0.01 )
Salkowski et al., J Immunol 1997 : To evaluate potential roles for macrophages, IFN-gamma, and TNF receptor 1 (TNFR1) in the regulation of LPS induced inducible nitric oxide synthase (iNOS) mRNA expression, we used a model of macrophage depletion as well as IFN-gamma ( GKO ) and TNFR1 (TNFR1 -/-) knockout mice ... Our results indicate that macrophages and/or their secreted products, endogenous IFN-gamma production, and TNFR1 mediated signaling play key roles in the in vivo regulation of iNOS mRNA expression and that the extent of their involvement is both time and organ specific