◀ Back to NOS2
NOS2 — TNFRSF1A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Alexander et al., Neurochem Int 2008
(Brain Diseases, Metabolic...) :
Furthermore, absence of
TNFR1 partially but significantly reduced the activation of astrocytes, as shown by immunofluorescence and markedly
inhibited iNOS mRNA expression ( p < 0.01 )
Salkowski et al., J Immunol 1997
:
To evaluate potential
roles for macrophages, IFN-gamma, and
TNF receptor 1 (TNFR1) in the regulation of LPS induced
inducible nitric oxide synthase (iNOS) mRNA expression, we used a model of macrophage depletion as well as IFN-gamma ( GKO ) and TNFR1 (TNFR1 -/-) knockout mice ... Our results indicate that macrophages and/or their secreted products, endogenous IFN-gamma production, and
TNFR1 mediated signaling
play key roles in the in vivo regulation of
iNOS mRNA expression and that the extent of their involvement is both time and organ specific